FGF23, Frailty, and Falls in SPRINT

BACKGROUND/OBJECTIVES Chronic kidney disease (CKD) is associated with frailty. Fibroblast growth factor 23 (FGF23) is elevated in CKD and associated with frailty among non‐CKD older adults and individuals with human immunodeficiency virus. Whether FGF23 is associated with frailty and falls in CKD is...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2021-02, Vol.69 (2), p.467-473
Main Authors: Jovanovich, Anna, Ginsberg, Charles, You, Zhiying, Katz, Ronit, Ambrosius, Walter T., Berlowitz, Dan, Cheung, Alfred K., Cho, Monique, Lee, Alexandra K., Punzi, Henry, Rehman, Shakaib, Roumie, Christianne, Supiano, Mark A., Wright, Clinton B., Shlipak, Michael, Ix, Joachim H., Chonchol, Michel
Format: Article
Language:English
Subjects:
Accidental Falls - statistics & numerical data
Aged
Antihypertensives
biomarkers
Biomarkers - blood
Blood pressure
chronic kidney disease
Cognitive ability
Correlation of Data
Cross-Sectional Studies
Demography
Diabetes mellitus
Epidermal growth factor receptors
Falls
Female
Fibroblast Growth Factor-23
Fibroblast Growth Factors - blood
Frailty
Frailty - blood
Frailty - epidemiology
Frailty - etiology
Frailty - physiopathology
Glomerular Filtration Rate
HIV
Human immunodeficiency virus
Humans
Kidney diseases
Male
Older people
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
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Summary:BACKGROUND/OBJECTIVES Chronic kidney disease (CKD) is associated with frailty. Fibroblast growth factor 23 (FGF23) is elevated in CKD and associated with frailty among non‐CKD older adults and individuals with human immunodeficiency virus. Whether FGF23 is associated with frailty and falls in CKD is unknown. DESIGN Cross‐sectional and longitudinal observational study. SETTING Systolic Blood Pressure Intervention Trial (SPRINT), a randomized trial evaluating standard (systolic blood pressure [SBP]
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.16895