Non-enzymatic glucose sensor based on a g-C3N4/NiO/CuO nanocomposite

• Published in: Analytical biochemistry 2021-03, Vol.616, p.114062-114062, Article 114062
• Main Authors: Lotfi, Z., Gholivand, M.B., Shamsipur, M.
• Format: Article
• Language: English
• Subjects: Amperometry; g-C3N4/NiO/CuO nanocomposite; Glucose sensor; Non-enzymatic sensor
• ISSN: 0003-2697; 1096-0309
• DOI: 10.1016/j.ab.2020.114062

In this paper, a non-enzymatic glucose sensor was developed based on a g-C3N4/NiO/CuO nanocomposite immobilized on a glassy carbon electrode (GCE). Field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Brunauer-Emmett-Teller (BET) were utilized for the characterization of the synthesized g-C3N4/NiO/CuO nanocomposite. The electrocatalytic activity of the nanocomposite was investigated by cyclic voltammetry, and the amperometric technique was applied for monitoring glucose. The g-C3N4/NiO/CuO/GCE exhibited better electrocatalytic performance than g-C3N4/GCE, g-C3N4/CuO/GCE and g-C3N4/NiO/GCE. Under optimized conditions, the proposed sensor offered a linearity ranging from 0.4 μM to 8.5 mM with a detection limit of 0.1 μM and a sensitivity of 362.12 μA mM−1 cm−2. The constructed sensor displayed favorable reproducibility, outstanding selectivity, and long-term performance. These results reveal that the sensor is a promising candidate for blood glucose sensing. [Display omitted] •g-C3N4/NiO/CuO nanocomposite as modifier was synthesized.•Glucose sensor was fabricated based on g-C3N4/NiO/CuO nanocomposite.•The designed sensor showed a wide linear range, low detection limit and high sensitivity.•The applicability of the sensor was evaluated in blood serum samples as real samples.