Social determinants of health, personalized medicine, and child maltreatment

This review begins with a brief summary of the importance of child maltreatment as a major public health problem, given its prevalence and the substantial human and economic costs involved. The focus then shifts to consideration of personalized medicine and child maltreatment, including genetic and...

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Bibliographic Details
Published in:Pediatric research 2021-01, Vol.89 (2), p.368-376
Main Authors: Lane, Wendy G., Dubowitz, Howard
Format: Article
Language:English
Subjects:
Child abuse & neglect
Genomics
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Precision medicine
Review Article
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Summary:This review begins with a brief summary of the importance of child maltreatment as a major public health problem, given its prevalence and the substantial human and economic costs involved. The focus then shifts to consideration of personalized medicine and child maltreatment, including genetic and genomics factors, as well as the role of social determinants of health. Research on epigenetics related to child abuse and neglect is presented, followed by that pertaining to a few specific social factors, such as poverty, parental depression and substance use, and domestic (or intimate partner) violence. The review ends with a discussion of interventions to help address social determinants of health with brief descriptions of several model programs, and thoughts concerning the role of personalized medicine in addressing child maltreatment in the foreseeable future. Impact This paper synthesizes knowledge on social determinants of health and advances in genetics and genomics related to the prevention of child maltreatment. It provides examples of model approaches to addressing the prevention of child maltreatment in primary care practices.
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-020-01290-9