Prospective therapeutic potential of Tanshinone IIA: An updated overview

In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an increasing scale. Tanshinone...

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Bibliographic Details
Published in:Pharmacological research 2021-02, Vol.164, p.105364-105364, Article 105364
Main Authors: Ansari, Mohammad Azam, Khan, Farheen Badrealam, Safdari, Haaris Ahsan, Almatroudi, Ahmad, Alzohairy, Mohammad A., Safdari, Mohammadreza, Amirizadeh, Mehran, Rehman, Suriya, Equbal, Mohammad Javed, Hoque, Mehboob
Format: Article
Language:English
Subjects:
Abietanes - administration & dosage
Animals
Anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-oxidant
Antioxidants - administration & dosage
Cancer
Cardiovascular disease
Drug Delivery Systems
Drug Therapy, Combination
Humans
Nanotherapeutics
Tanshinone
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Summary:In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an increasing scale. Tanshinone IIA (Tan IIA) is a pharmacologically active lipophilic component of Salvia miltiorrhiza extract. Tan IIA shares a history of high repute in Traditional Chinese Medicine. Reckoning with these, the present review collates the pharmacological properties of Tan IIA with a special emphasis on its therapeutic potential against diverse diseases including cardiovascular diseases, cerebrovascular diseases, cancer, diabetes, obesity and neurogenerative diseases. Further, possible applications of various therapeutic preparations of Tan IIA were discussed with special emphasis on nano-based drug delivery formulations. Considering the tremendous advancement in the field of nanomedicine and the therapeutic potential of Tan IIA, the convergence of these two aspects can be foreseen with great promise in clinical application.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2020.105364