Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue

N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m A in hepatocellular carcinoma (HCC) remain unclear. We analyzed 177 HCC and paired noncancerous liver tissues from patients who underwent hep...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2020-12, Vol.40 (12), p.6665-6676
Main Authors: Nakagawa, Nobuhiko, Tanaka, Katsuhito, Sonohara, Fuminori, Kandimalla, Raju, Sunagawa, Yuki, Inokawa, Yoshikuni, Takami, Hideki, Hayashi, Masamichi, Yamada, Suguru, Kanda, Mitsuro, Tanaka, Chie, Nakayama, Goro, Koike, Masahiko, Kodera, Yasuhiro
Format: Article
Language:English
Subjects:
Adenosine - analogs & derivatives
Adenosine - metabolism
Adult
Aged
Aged, 80 and over
AlkB Homolog 5, RNA Demethylase - genetics
AlkB Homolog 5, RNA Demethylase - metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism
Body fat
Cancer
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Dioxygenase
Female
Gene Expression Regulation, Neoplastic
Hepatectomy
Hepatocellular carcinoma
Homology
Humans
Kaplan-Meier Estimate
Ketoglutaric acid
Liver
Liver - metabolism
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Methylation
Middle Aged
Multivariate Analysis
N6-methyladenosine
Prognosis
Proportional Hazards Models
Ribonucleic acid
RNA
RNA - metabolism
RNA modification
Survival Analysis
Tissues
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m A in hepatocellular carcinoma (HCC) remain unclear. We analyzed 177 HCC and paired noncancerous liver tissues from patients who underwent hepatectomy according to global m A quantification and expression of m A demethylases fat mass and obesity-associated protein (FTO) and alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5). The global m A quantification revealed no significant difference between HCC and non-cancerous tissue. The expression of m A demethylases FTO and ALKBH5, was significantly lower in HCC than in non-cancerous tissues (both p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14690