The functions of mechanosensitive ion channels in tooth and bone tissues

• Published in: Cellular signalling 2021-02, Vol.78, p.109877-109877, Article 109877
• Main Authors: Pei, Fang, Liu, Jialing, Zhang, Lan, Pan, Xuefeng, Huang, Wei, Cen, Xiao, Huang, Shishu, Jin, Ying, Zhao, Zhihe
• Format: Article
• Language: English
• Subjects: Animals; Bone and Bones - metabolism; Disease; Humans; Ion Channels - metabolism; Mechanosensitive ion channels; Mechanosensitivity; Mechanotransduction, Cellular; Tooth - metabolism; Tooth，Bone，Functions
• ISSN: 0898-6568; 1873-3913
• DOI: 10.1016/j.cellsig.2020.109877

Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thus, mechanotransduction is a key process in many developmental, physiological and pathological processes in tooth and bone. Mechanosensitive ion channels such as Piezo1 and Piezo2 are important participants in mechanotransduction, but their functions in tooth and bone are poorly understood. This review summarizes our current understanding of mechanosensitive ion channels and their roles in tooth and bone tissues. Research in these areas may shed new light on the regulation of tooth and bone tissues and potential treatments for diseases affecting these tissues. •Both tooth and bone tissue are highly calcified tissues, sensitive to mechanical stimulation.•Mechanosensitive ion channels play important roles in development, function and pathological state of tooth and bone.•This review summarizes the kinds, functions, diseases and related signaling pathways of MSCs in tooth and bone tissues.•This review provides ideas for the study of dental and skeletal diseases and tissue regeneration.