Malignant hyperthermia during pediatric kidney transplantation—A medical and ethical quandary

• Published in: Pediatric transplantation 2021-05, Vol.25 (3), p.e13923-n/a
• Main Authors: Srinivasan, Sangeeth P., Eldo, Nidhin, Nair, Suresh G.
• Format: Article
• Language: English
• Subjects: Bioethical Issues; Child, Preschool; Depolarization; ethical dilemma; Ethics; Fever; Hemodynamics; Humans; Hypercapnia; Hyperthermia; Intraoperative Care - ethics; Intubation; Kidney Failure, Chronic - surgery; Kidney Transplantation; Kidney transplants; live donor transplant; Male; Malignant hyperthermia; malignant hyperthermia (MH); Malignant Hyperthermia - therapy; Medical ethics; Muscle relaxants; pediatric kidney transplant; Pediatrics; Perfusion; perioperative challenges; Reperfusion; Tachycardia
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/petr.13923

Malignant hyperthermia (MH) is a rare life‐threatening anesthetic complication with high mortality rates. MH during adult kidney transplant has been reported previously. However, the occurrence of MH after multiple previous uneventful anesthetic exposures in a pediatric kidney transplant recipient is rare. To our knowledge, this is the first reported case of MH in a child undergoing a live donor kidney transplant. The approaches for addressing perioperative challenges and ethical dilemmas to ensure successful outcomes are described. The recipient, a 5‐year‐old male child, weighing 20 kg, with a history of multiple previous uneventful anesthetic exposures, underwent live donor kidney transplant for end‐stage renal disease (ESRD). Post‐reperfusion he developed fulminant MH with rapidly progressing hyperthermia, hypercarbia, tachycardia, and muscle rigidity, which in addition to complicating the medical management raised several ethical issues as well. MH was successfully managed with dantrolene and other supportive measures. Judicious use of inotropes and fluids helped maintain stable hemodynamics and graft perfusion. Management of MH is complicated in a pediatric patient with ESRD undergoing live donor kidney transplant. Preference for non‐depolarizing muscle relaxants instead of succinylcholine during endotracheal intubation can result in delayed onset of clinical manifestations. However, the metabolic complications may be more severe due to preexisting electrolyte and acid‐base disturbances. Maintaining optimal graft perfusion while simultaneously combating MH can be very challenging in a child. Since the allograft is a precious commodity, critical decisions regarding the harvesting of the donor kidney need to be well thought out. Early diagnosis and prompt treatment with dantrolene are critical to preserving graft function and the recipient's life.