Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp

Four new polyhydroxylated steroids plaksterols A–D (1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol (5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2020-11, Vol.18 (11), p.844-849
Main Authors: WANG, Kun-Ya, LI, Ping-Lin, SUN, Jing-Fan, de Voogd, Nicole J., TANG, Xu-Li, LI, Guo-Qiang
Format: Article
Language:English
Subjects:
Cytotoxic activity
Plakortis sp
Polyhydroxylated steroids
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Summary:Four new polyhydroxylated steroids plaksterols A–D (1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol (5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(20)60026-7