Ultrafast Surface Plasmon Resonance Imaging Sensor via the High-Precision Four-Parameter-Based Spectral Curve Readjusting Method

A variety of surface plasmon resonance (SPR) sensing devices have been extensively used in biochemical detection for their characteristics of label-free, highly sensitive, and faster detecting. Among them, the spectrum-based SPR sensing devices have offered us great advantages in high-throughput sen...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2021-01, Vol.93 (2), p.828-833
Main Authors: Wang, Xueliang, Zeng, Youjun, Zhou, Jie, Chen, Jiajie, Miyan, Ruibiao, Zhang, Han, Qu, Junle, Ho, Ho-Pui, Gao, Bruce Zhi, Shao, Yonghong
Format: Article
Language:English
Subjects:
Algorithms
Black carbon
Carbon
Carbon black
Chemistry
Coal mines
COVID-19 - diagnosis
COVID-19 - virology
Electric power generation
Electrical measurement
Electrochemical analysis
Electrochemistry
Environmental conditions
Humans
Industrial engineering
Industrial plants
Limit of Detection
Manufacturing engineering
Microelectrodes
Optics and Photonics
Power plants
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - metabolism
Spike Glycoprotein, Coronavirus - analysis
Spike Glycoprotein, Coronavirus - metabolism
Spikes
Surface plasmon resonance
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
Temperature
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Summary:A variety of surface plasmon resonance (SPR) sensing devices have been extensively used in biochemical detection for their characteristics of label-free, highly sensitive, and faster detecting. Among them, the spectrum-based SPR sensing devices have offered us great advantages in high-throughput sensing due to their large dynamic range and the possibility of detection resolution similar to that offered by angle interrogation. This paper demonstrates a spectrum-based SPR imaging sensing system with fast wavelength scanning capability achieved by an acousto-optic tunable filter (AOTF) and a low-cost and speckle-free halogen lamp implemented as the SPR excitation source. Especially, we developed a novel four-parameter-based spectral curve readjusting (4-PSCR) method for data processing, which offered us a faster and more accurate spectral data curve fitting process than the traditional polynomial fitting method. With the configuration, we have also conducted an SPR high-throughput detection of the novel coronavirus (COVID-19) spike protein, proving its application possibility in the screening of COVID-19 with high accuracy. We believe that the higher sensitivity and accuracy of the system have made it readily used in biochemical imaging and detecting applications.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.0c03347