High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders

•Subjects with MS and NMOSD have higher sNfL levels as compared to HCs.•Higher sNfL levels during an MS or NMOSD attack.•Lower levels among subjects treated with immunosuppressants for NMOSD subjects.•sNfL levels were not significantly different between CSF OCB-positive and negative patients. Serum...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2021-01, Vol.83, p.108-111
Main Authors: Liu, Chunxin, Zhao, Lin, Fan, Ping, Ko, Ho, Au, Cheryl, Ng, Angel, Au, Lisa, Wong, Adrian, Kermode, Allan G., Mok, Vincent, Yan, Yaping, Qiu, Wei, Lau, Alexander Y.
Format: Article
Language:English
Subjects:
Adult
Aquaporin 4 - immunology
Asian Continental Ancestry Group
Biomarkers - blood
China
Chinese
Cohort Studies
Cross-Sectional Studies
Female
Humans
Immunoglobulin G - immunology
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - immunology
Neurofilament Proteins - blood
Neuromyelitis Optica - blood
Neuromyelitis Optica - immunology
Neuromyelitis optica spectrum disorders
Oligoclonal Bands - immunology
Serum neurofilament light chain
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Summary:•Subjects with MS and NMOSD have higher sNfL levels as compared to HCs.•Higher sNfL levels during an MS or NMOSD attack.•Lower levels among subjects treated with immunosuppressants for NMOSD subjects.•sNfL levels were not significantly different between CSF OCB-positive and negative patients. Serum neurofilament light chain (sNfL) is a promising biomarker for neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS), but there is limited validation data in specific ethnic and disease groups. To investigate the levels of sNfL in a cohort of Chinese patients with NMOSD and compare sNfL levels in patients with different disease courses and treatments. We analysed sNfL levels in 153 Chinese patients with NMOSD (n = 51) and MS (n = 102) using single-molecule array (Simoa) technology. The sNfL levels were compared with those of 71 healthy controls from two centres in southern China. For each disease, we assessed correlations between sNfL and disease phases and treatments. Higher levels of sNfL were found in the patients with NMOSD [17.97 (10.55–27.94) pg/mL] and MS [15.83 (8.92–25.67) pg/mL] compared to healthy controls [10.09 (7.19–13.29) pg/mL, p 
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2020.11.016