Serum uric acid is associated with increased risk of posttransplantation diabetes in kidney transplant recipients: a prospective cohort study

Serum uric acid (SUA) is associated with fasting glucose in healthy subjects, and prospective epidemological studies have shown that elevated SUA is associated with increased risk of type 2 diabetes. Whether SUA is independently associated with higher risk of posttransplantation diabetes mellitus (P...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2021-03, Vol.116, p.154465-154465, Article 154465
Main Authors: Sotomayor, Camilo G., Oskooei, Sara Sokooti, Bustos, Nicolás I., Nolte, Ilja M., Gomes-Neto, António W., Erazo, Marcia, Gormaz, Juan G., Berger, Stefan P., Navis, Gerjan J., Rodrigo, Ramón, Dullaart, Robin P.F., Bakker, Stephan J.L.
Format: Article
Language:English
Subjects:
Adult
Aged
Cohort Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - etiology
Female
Glomerular Filtration Rate
Humans
Inflammation
Kidney transplantation
Kidney Transplantation - adverse effects
Longitudinal Studies
Male
Metabolic syndrome
Middle Aged
Oxidative stress
Posttransplantation diabetes
Prospective Studies
Risk Factors
Transplant Recipients
Uric acid
Uric Acid - blood
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Summary:Serum uric acid (SUA) is associated with fasting glucose in healthy subjects, and prospective epidemological studies have shown that elevated SUA is associated with increased risk of type 2 diabetes. Whether SUA is independently associated with higher risk of posttransplantation diabetes mellitus (PTDM) in kidney transplant recipients (KTR) remains unknown. We performed a longitudinal cohort study of 524 adult KTR with a functioning graft ≥1-year, recruited at a university setting (2008–2011). Multivariable-adjusted Cox proportional-hazards regression analyses were performed to assess the association between time-updated SUA and risk of PTDM (defined according the American Diabetes Association's diagnostic criteria). Mean (SD) SUA was 0.43 (0.11) mmol/L at baseline. During 5.3 (IQR, 4.1–6.0) years of follow-up, 52 (10%) KTR developed PTDM. In univariate prospective analyses, SUA was associated with increased risk of PTDM (HR 1.75, 95% CI 1.36–2.26 per 1-SD increment; P 50%).•Calcineurin inhibitors, specially cyclosporine, associate with higher uric acid.•Higher uric acid is associated with increased risk of posttransplant diabetes•Uric acid-targeted care may aid on decreasing the burden of posttranplant diabetes.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2020.154465