Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke

To analyze the temporal trends of atrial fibrillation (AF)-related ischemic stroke (IS) and their relationship with the prescription patterns of antithrombotic treatment from 2013 to 2019 in the Health Assistance Area of a regional hospital. First, a retrospective ecological study of aggregate data...

Full description

Saved in:
Bibliographic Details
Published in:Current medical research and opinion 2021-03, Vol.37 (3), p.357-365
Main Authors: Freixa-Pamias, Román, Blanch Gràcia, Pedro, Rodríguez Latre, Maria Lluïsa, Basile, Luca, Sanchez Chamero, Pilar, Gomez-Choco, Manuel, Armario, Pedro, Martínez-Rubio, Antoni, Lupón, Josep
Format: Article
Language:English
Subjects:
Anticoagulation
aspirin
atrial fibrillation
direct oral anticoagulants
stroke
vitamin K antagonist
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833
cites cdi_FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833
container_end_page 365
container_issue 3
container_start_page 357
container_title Current medical research and opinion
container_volume 37
creator Freixa-Pamias, Román
Blanch Gràcia, Pedro
Rodríguez Latre, Maria Lluïsa
Basile, Luca
Sanchez Chamero, Pilar
Gomez-Choco, Manuel
Armario, Pedro
Martínez-Rubio, Antoni
Lupón, Josep
description To analyze the temporal trends of atrial fibrillation (AF)-related ischemic stroke (IS) and their relationship with the prescription patterns of antithrombotic treatment from 2013 to 2019 in the Health Assistance Area of a regional hospital. First, a retrospective ecological study of aggregate data to analyze the annual incidence of IS between 2013 and 2019 was performed. Second, we selected those patients diagnosed with AF between 2013 and 2019 and performed a retrospective longitudinal study to assess the role of antithrombotic therapy in the development of AF-related IS. During this period, whereas the annual incidence of IS remained stable (from 1.3 in 2013 to 1.2 cases per 1000 inhabitants in 2019; adjusted P for trend .829), the annual incidence of AF-related IS decreased over time (from 23.8 to 18.8 cases per 1000 inhabitants, respectively; adjusted P for trend .001). Among AF patients, the use of direct oral anticoagulants increased from 5.5% to 46.8%, while the prescription of antiplatelets and vitamin K antagonists decreased from 21.9% to 6.0% and from 63.8% to 36.1%, respectively. Overall, the use of oral anticoagulants increased from 69.3% to 82.9%; p 
doi_str_mv 10.1080/03007995.2020.1865892
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2470897818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2470897818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EotvCI4By5JLi2E4yvoEqoJUqcYGzNXEmqksSh7FXqG-Po91y5GJb4--bGf1CvGvkdSNBfpRayt7a9lpJVUrQtWDVC3FoTK9rA33_Uhx2pt6hC3GZ0qOUjQJrX4sLrbXqtDQH8Xi3bOhzFadqY0qew5ZDXKsNcyZe0_6Baw75geMyxBx8lZkwL7QWaa0wc8C5msLAYZ5xd2um8qCxCsk_0FKMlDn-ojfi1YRzorfn-0r8_Prlx81tff_9293N5_va667LNZVTNuSRYLK-kx5hbIdWKQ8oR7DGkhqMNmNnDAwNyJbaCVtCAOoItL4SH059N46_j5SyW8omVLZbKR6TU6aXYHtooKDtCfUcU2Ka3MZhQX5yjXR7zO45ZrfH7M4xF-_9ecRxWGj8Zz3nWoBPJyCsU-QF_0SeR5fxaY48Ma4-JKf_P-MvpQiO1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2470897818</pqid></control><display><type>article</type><title>Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Freixa-Pamias, Román ; Blanch Gràcia, Pedro ; Rodríguez Latre, Maria Lluïsa ; Basile, Luca ; Sanchez Chamero, Pilar ; Gomez-Choco, Manuel ; Armario, Pedro ; Martínez-Rubio, Antoni ; Lupón, Josep</creator><creatorcontrib>Freixa-Pamias, Román ; Blanch Gràcia, Pedro ; Rodríguez Latre, Maria Lluïsa ; Basile, Luca ; Sanchez Chamero, Pilar ; Gomez-Choco, Manuel ; Armario, Pedro ; Martínez-Rubio, Antoni ; Lupón, Josep ; Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain ; Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</creatorcontrib><description>To analyze the temporal trends of atrial fibrillation (AF)-related ischemic stroke (IS) and their relationship with the prescription patterns of antithrombotic treatment from 2013 to 2019 in the Health Assistance Area of a regional hospital. First, a retrospective ecological study of aggregate data to analyze the annual incidence of IS between 2013 and 2019 was performed. Second, we selected those patients diagnosed with AF between 2013 and 2019 and performed a retrospective longitudinal study to assess the role of antithrombotic therapy in the development of AF-related IS. During this period, whereas the annual incidence of IS remained stable (from 1.3 in 2013 to 1.2 cases per 1000 inhabitants in 2019; adjusted P for trend .829), the annual incidence of AF-related IS decreased over time (from 23.8 to 18.8 cases per 1000 inhabitants, respectively; adjusted P for trend .001). Among AF patients, the use of direct oral anticoagulants increased from 5.5% to 46.8%, while the prescription of antiplatelets and vitamin K antagonists decreased from 21.9% to 6.0% and from 63.8% to 36.1%, respectively. Overall, the use of oral anticoagulants increased from 69.3% to 82.9%; p &lt; .001. Patients under antiplatelet agents had a higher probability of presenting IS than those patients taking oral anticoagulants, either vitamin K antagonists or direct oral anticoagulants (adjusted OR 1.89; 95% CI 1.52-2.37; p &lt; .001). The prescription of oral anticoagulants, particularly direct oral anticoagulants, has increased from 2013 to 2019 in our Health Assistance Area. This increase might partially explain the reduction in AF-related IS.</description><identifier>ISSN: 0300-7995</identifier><identifier>EISSN: 1473-4877</identifier><identifier>DOI: 10.1080/03007995.2020.1865892</identifier><identifier>PMID: 33326304</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Anticoagulation ; aspirin ; atrial fibrillation ; direct oral anticoagulants ; stroke ; vitamin K antagonist</subject><ispartof>Current medical research and opinion, 2021-03, Vol.37 (3), p.357-365</ispartof><rights>2021 Informa UK Limited, trading as Taylor &amp; Francis Group 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833</citedby><cites>FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33326304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freixa-Pamias, Román</creatorcontrib><creatorcontrib>Blanch Gràcia, Pedro</creatorcontrib><creatorcontrib>Rodríguez Latre, Maria Lluïsa</creatorcontrib><creatorcontrib>Basile, Luca</creatorcontrib><creatorcontrib>Sanchez Chamero, Pilar</creatorcontrib><creatorcontrib>Gomez-Choco, Manuel</creatorcontrib><creatorcontrib>Armario, Pedro</creatorcontrib><creatorcontrib>Martínez-Rubio, Antoni</creatorcontrib><creatorcontrib>Lupón, Josep</creatorcontrib><creatorcontrib>Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</creatorcontrib><creatorcontrib>Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</creatorcontrib><title>Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke</title><title>Current medical research and opinion</title><addtitle>Curr Med Res Opin</addtitle><description>To analyze the temporal trends of atrial fibrillation (AF)-related ischemic stroke (IS) and their relationship with the prescription patterns of antithrombotic treatment from 2013 to 2019 in the Health Assistance Area of a regional hospital. First, a retrospective ecological study of aggregate data to analyze the annual incidence of IS between 2013 and 2019 was performed. Second, we selected those patients diagnosed with AF between 2013 and 2019 and performed a retrospective longitudinal study to assess the role of antithrombotic therapy in the development of AF-related IS. During this period, whereas the annual incidence of IS remained stable (from 1.3 in 2013 to 1.2 cases per 1000 inhabitants in 2019; adjusted P for trend .829), the annual incidence of AF-related IS decreased over time (from 23.8 to 18.8 cases per 1000 inhabitants, respectively; adjusted P for trend .001). Among AF patients, the use of direct oral anticoagulants increased from 5.5% to 46.8%, while the prescription of antiplatelets and vitamin K antagonists decreased from 21.9% to 6.0% and from 63.8% to 36.1%, respectively. Overall, the use of oral anticoagulants increased from 69.3% to 82.9%; p &lt; .001. Patients under antiplatelet agents had a higher probability of presenting IS than those patients taking oral anticoagulants, either vitamin K antagonists or direct oral anticoagulants (adjusted OR 1.89; 95% CI 1.52-2.37; p &lt; .001). The prescription of oral anticoagulants, particularly direct oral anticoagulants, has increased from 2013 to 2019 in our Health Assistance Area. This increase might partially explain the reduction in AF-related IS.</description><subject>Anticoagulation</subject><subject>aspirin</subject><subject>atrial fibrillation</subject><subject>direct oral anticoagulants</subject><subject>stroke</subject><subject>vitamin K antagonist</subject><issn>0300-7995</issn><issn>1473-4877</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMFu1DAQhi0EotvCI4By5JLi2E4yvoEqoJUqcYGzNXEmqksSh7FXqG-Po91y5GJb4--bGf1CvGvkdSNBfpRayt7a9lpJVUrQtWDVC3FoTK9rA33_Uhx2pt6hC3GZ0qOUjQJrX4sLrbXqtDQH8Xi3bOhzFadqY0qew5ZDXKsNcyZe0_6Baw75geMyxBx8lZkwL7QWaa0wc8C5msLAYZ5xd2um8qCxCsk_0FKMlDn-ojfi1YRzorfn-0r8_Prlx81tff_9293N5_va667LNZVTNuSRYLK-kx5hbIdWKQ8oR7DGkhqMNmNnDAwNyJbaCVtCAOoItL4SH059N46_j5SyW8omVLZbKR6TU6aXYHtooKDtCfUcU2Ka3MZhQX5yjXR7zO45ZrfH7M4xF-_9ecRxWGj8Zz3nWoBPJyCsU-QF_0SeR5fxaY48Ma4-JKf_P-MvpQiO1A</recordid><startdate>20210304</startdate><enddate>20210304</enddate><creator>Freixa-Pamias, Román</creator><creator>Blanch Gràcia, Pedro</creator><creator>Rodríguez Latre, Maria Lluïsa</creator><creator>Basile, Luca</creator><creator>Sanchez Chamero, Pilar</creator><creator>Gomez-Choco, Manuel</creator><creator>Armario, Pedro</creator><creator>Martínez-Rubio, Antoni</creator><creator>Lupón, Josep</creator><general>Taylor &amp; Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210304</creationdate><title>Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke</title><author>Freixa-Pamias, Román ; Blanch Gràcia, Pedro ; Rodríguez Latre, Maria Lluïsa ; Basile, Luca ; Sanchez Chamero, Pilar ; Gomez-Choco, Manuel ; Armario, Pedro ; Martínez-Rubio, Antoni ; Lupón, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticoagulation</topic><topic>aspirin</topic><topic>atrial fibrillation</topic><topic>direct oral anticoagulants</topic><topic>stroke</topic><topic>vitamin K antagonist</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freixa-Pamias, Román</creatorcontrib><creatorcontrib>Blanch Gràcia, Pedro</creatorcontrib><creatorcontrib>Rodríguez Latre, Maria Lluïsa</creatorcontrib><creatorcontrib>Basile, Luca</creatorcontrib><creatorcontrib>Sanchez Chamero, Pilar</creatorcontrib><creatorcontrib>Gomez-Choco, Manuel</creatorcontrib><creatorcontrib>Armario, Pedro</creatorcontrib><creatorcontrib>Martínez-Rubio, Antoni</creatorcontrib><creatorcontrib>Lupón, Josep</creatorcontrib><creatorcontrib>Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</creatorcontrib><creatorcontrib>Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current medical research and opinion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freixa-Pamias, Román</au><au>Blanch Gràcia, Pedro</au><au>Rodríguez Latre, Maria Lluïsa</au><au>Basile, Luca</au><au>Sanchez Chamero, Pilar</au><au>Gomez-Choco, Manuel</au><au>Armario, Pedro</au><au>Martínez-Rubio, Antoni</au><au>Lupón, Josep</au><aucorp>Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</aucorp><aucorp>Working Group for coordination between Cardiology &amp; Primary Care, Barcelona, Spain</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke</atitle><jtitle>Current medical research and opinion</jtitle><addtitle>Curr Med Res Opin</addtitle><date>2021-03-04</date><risdate>2021</risdate><volume>37</volume><issue>3</issue><spage>357</spage><epage>365</epage><pages>357-365</pages><issn>0300-7995</issn><eissn>1473-4877</eissn><abstract>To analyze the temporal trends of atrial fibrillation (AF)-related ischemic stroke (IS) and their relationship with the prescription patterns of antithrombotic treatment from 2013 to 2019 in the Health Assistance Area of a regional hospital. First, a retrospective ecological study of aggregate data to analyze the annual incidence of IS between 2013 and 2019 was performed. Second, we selected those patients diagnosed with AF between 2013 and 2019 and performed a retrospective longitudinal study to assess the role of antithrombotic therapy in the development of AF-related IS. During this period, whereas the annual incidence of IS remained stable (from 1.3 in 2013 to 1.2 cases per 1000 inhabitants in 2019; adjusted P for trend .829), the annual incidence of AF-related IS decreased over time (from 23.8 to 18.8 cases per 1000 inhabitants, respectively; adjusted P for trend .001). Among AF patients, the use of direct oral anticoagulants increased from 5.5% to 46.8%, while the prescription of antiplatelets and vitamin K antagonists decreased from 21.9% to 6.0% and from 63.8% to 36.1%, respectively. Overall, the use of oral anticoagulants increased from 69.3% to 82.9%; p &lt; .001. Patients under antiplatelet agents had a higher probability of presenting IS than those patients taking oral anticoagulants, either vitamin K antagonists or direct oral anticoagulants (adjusted OR 1.89; 95% CI 1.52-2.37; p &lt; .001). The prescription of oral anticoagulants, particularly direct oral anticoagulants, has increased from 2013 to 2019 in our Health Assistance Area. This increase might partially explain the reduction in AF-related IS.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>33326304</pmid><doi>10.1080/03007995.2020.1865892</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0300-7995
ispartof Current medical research and opinion, 2021-03, Vol.37 (3), p.357-365
issn 0300-7995
1473-4877
language eng
recordid cdi_proquest_miscellaneous_2470897818
source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Anticoagulation
aspirin
atrial fibrillation
direct oral anticoagulants
stroke
vitamin K antagonist
title Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A05%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20prescription%20patterns%20of%20antithrombotic%20treatment%20on%20atrial%20fibrillation-related%20ischemic%20stroke&rft.jtitle=Current%20medical%20research%20and%20opinion&rft.au=Freixa-Pamias,%20Rom%C3%A1n&rft.aucorp=Working%20Group%20for%20coordination%20between%20Cardiology%20&%20Primary%20Care,%20Barcelona,%20Spain&rft.date=2021-03-04&rft.volume=37&rft.issue=3&rft.spage=357&rft.epage=365&rft.pages=357-365&rft.issn=0300-7995&rft.eissn=1473-4877&rft_id=info:doi/10.1080/03007995.2020.1865892&rft_dat=%3Cproquest_pubme%3E2470897818%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c366t-e36601ecae8f9c60ca8d5b522c8a0d8949e2b434d6448b1805e5fa5ea88e6e833%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2470897818&rft_id=info:pmid/33326304&rfr_iscdi=true