Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles

A novel approach to 2,5-disubstituted 1,3,4-oxadiazoles derivatives via a decarboxylative cyclization reaction by photoredox catalysis between commercially available α-oxocarboxylic acids and hypervalent iodine­(III) reagent is described. This powerful transformation involves the coupling reaction b...

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Bibliographic Details
Published in:Organic letters 2020-12, Vol.22 (24), p.9621-9626
Main Authors: Li, Jian, Lu, Xue-Chen, Xu, Yue, Wen, Jin-Xia, Hou, Guo-Quan, Liu, Li
Format: Article
Language:English
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Summary:A novel approach to 2,5-disubstituted 1,3,4-oxadiazoles derivatives via a decarboxylative cyclization reaction by photoredox catalysis between commercially available α-oxocarboxylic acids and hypervalent iodine­(III) reagent is described. This powerful transformation involves the coupling reaction between two different kinds of radical species and the formation of C–N and C–O bonds.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c03663