Utility of quantitative ultrasound in community screening for hepatic steatosis

• Published in: Ultrasonics 2021-03, Vol.111, p.106329-106329, Article 106329
• Main Authors: Chang, Tu-Yung, Chang, Shu-Hung, Lin, Ying-Hsiu, Ho, Wen-Chao, Wang, Chiao-Yin, Jeng, Wen-Juei, Wan, Yung-Liang, Tsui, Po-Hsiang
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cross-Sectional Studies; Female; Hepatic steatosis; Humans; Male; Mass Screening; Middle Aged; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Nonalcoholic fatty liver disease; Prospective Studies; Quantitative ultrasound; Taiwan; Ultrasonography - methods
• ISSN: 0041-624X; 1874-9968
• DOI: 10.1016/j.ultras.2020.106329

•Quantitative ultrasound (QUS) clinically grades hepatic steatosis.•The utility of QUS for community screening of hepatic steatosis remains unclear.•Entropy, integrated backscatter, and controlled attenuation parameter were explored.•Entropy outperformed the other indices in community screening of hepatic steatosis. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Quantitative ultrasound facilitates clinical grading of hepatic steatosis (the early stage of NAFLD). However, the utility of quantitative ultrasound as a first-line method for community screening of hepatic steatosis remains unclear. Therefore, this study aimed to investigate the utility of quantitative ultrasound to screen for hepatic steatosis and for metabolic evaluation at the community level. In total, 278 participants enrolled from a community satisfied the study criteria. Each subject underwent anthropometric and biochemical examinations, and abdominal ultrasound imaging was performed to measure the controlled attenuation (CAP), integrated backscatter (IB), and information Shannon entropy (ISE). The assessment outcomes were compared with the fatty liver index (FLI), hepatic steatosis index (HSI), metabolic syndrome (MetS), and insulin resistance to evaluate the screening performance through the area under the receiver operating characteristic curve (AUROC) and Delong’s test. Ultrasound ISE, CAP, and IB were effective in screening hepatic steatosis, MetS, and insulin resistance. In screening for hepatic steatosis, the AUROCs of ISE, CAP, and IB were 0.85, 0.83, and 0.80 (the cutoff FLI = 60), respectively, and 0.84, 0.75, 0.77 (the cutoff HSI = 36), respectively, and those for the evaluation of MetS and insulin resistance were 0.79, 0.75, 0.79, respectively, and 0.83, 0.76, 0.78, respectively. Delong’s test revealed that ISE outperformed CAP and IB for the detection of hepatic steatosis and insulin resistance (P