Phytochemical profile and antioxidant activity of Dracocephalum moldavica L. seed extracts using different extraction methods

•We analyzed the bioactive compounds and antioxidant activity of DM seed extracts.•Alpha-linolenic acid was the most abundant fatty acid in DM seed.•Phytosterol composition by supercritical fluid CO2 extraction is first reported in DM seed.•Our study highlights the importance of appropriate extracti...

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Bibliographic Details
Published in:Food chemistry 2021-07, Vol.350, p.128531-128531, Article 128531
Main Authors: Song, Eunsu, Choi, Jaeyoung, Gwon, Hyeeun, Lee, Kyo-Yeon, Choi, Sung-Gil, Atiqual Islam, Md, Chun, Jiyeon, Hwang, Jinah
Format: Article
Language:English
Subjects:
Alpha-linolenic acid
Antioxidant
Antioxidants - chemistry
Antioxidants - pharmacology
Dracocephalum moldavica
Flavonoid
Lamiaceae - embryology
Phytochemicals - analysis
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Polyphenol
Seeds - chemistry
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Summary:•We analyzed the bioactive compounds and antioxidant activity of DM seed extracts.•Alpha-linolenic acid was the most abundant fatty acid in DM seed.•Phytosterol composition by supercritical fluid CO2 extraction is first reported in DM seed.•Our study highlights the importance of appropriate extraction conditions.•Our study provides a basis for future research and application of DM seed and its rich ω-3 fatty acids. Dracocephalum moldavica L. (DM) is used to treat cardiovascular diseases and dermatitis. However, the properties of DM seed and its extracts remain unclear. We analyzed the bioactive compounds and antioxidant activity of aqueous extract (AE), ethanolic extract (EE), and supercritical CO2 extracted oil (SC-oil) of DM seed. Alpha-linolenic acid was the most abundant fatty acid (51.4–61.6%) with an ω-3 to ω-6 ratio of 2.93–3.42 to 1. Stigmasterol and β-sitosterol + fucosterol were the main components of DM seed extracts, and campesterol was detected only in SC-oil. The total tocopherol content, especially γ-tocopherol, was 60% higher in EE than in AE and SC-oil, whereas β-carotene was detected only in SC-oil. The content of total phenols and flavonoids was the highest in EE. Rosmarinic acid, apigenin, and caffeic acid were detected only in EE. The radical scavenging activity of EE was the highest in EE. The results can help promote DM application.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2020.128531