Biodegradable dendritic Boltorn™ nanoconstructs: A promising avenue for cancer theranostics

[Display omitted] •Boltorn™ H40 has emerged as a boon for targeted anti-cancer drug delivery.•GSH-responsive DOX-H40 NPs showed significantly high cytotoxicity in HeLa cells.•GE11-GFP siRNA-H40 NPs exhibited excellent gene silencing in TNBC cells.•HCPT-H40-star-NPs showed excellent antitumor activit...

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Bibliographic Details
Published in:International journal of pharmaceutics 2021-02, Vol.594, p.120177-120177, Article 120177
Main Authors: Korake, S., Shaikh, A., Salve, R., Gajbhiye, K.R., Gajbhiye, V., Pawar, A.
Format: Article
Language:English
Subjects:
Dendrimers
NE cancers
Polyester
Targeted cancer therapy
Theranostic
Unimolecular micelles
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Summary:[Display omitted] •Boltorn™ H40 has emerged as a boon for targeted anti-cancer drug delivery.•GSH-responsive DOX-H40 NPs showed significantly high cytotoxicity in HeLa cells.•GE11-GFP siRNA-H40 NPs exhibited excellent gene silencing in TNBC cells.•HCPT-H40-star-NPs showed excellent antitumor activity in MCF-7 tumor-bearing mice.•OCT-tethering triggered 12-fold higher uptake in thyroid medullary carcinoma cells.•cRGD/NOTA-H40 NPs exhibited excellent theranostic potential against brain tumor. The family of Boltorn™ H40 dendrimers is an imperative subclass of hyperbranched biodegradable polymers (HBPs), which has received mounting attention as a result of its inimitable chemical, physical and biodegradable properties. These properties embrace three-dimensional dendrimeric nanoarchitecture to avert tanglement between polymer branches, adequate spatial cavities for increased encapsulation of guest molecules, good solubility as well as low viscosity to improve processability, and a huge number of surface functional groups for chemical manipulations. Similarly, low toxicity, non-immunogenicity, and natural biodegradation are significant and critical advantages in therapeutic applications as compared to other dendritic polymers. All these characteristics of Boltorn™ H40 are of pronounced importance for planning and developing advanced targeted cargo delivery carriers for cancer therapy. The present review highlights the applications of Boltorn™ H40 HBPs for the transport of chemotherapeutic agents to manage various types of cancers.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2020.120177