Survival and prognostic association in stage IV colorectal cancer patients treated with chemotherapy in Bangladesh

Prognostic factors in colorectal cancer have lesser been evaluated in developing countries. This study aims to determine overall survival and prognostic factors for metastatic colorectal cancer patients who were non-operable and received chemotherapy. The study retrospectively investigated 67 inoper...

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Published in:Japanese journal of clinical oncology 2021-04, Vol.51 (4), p.552-559
Main Authors: Shuayb, Md, Mehedi Hasan, Md, Hoque, Md Rashedul, Mushtaq Hussain, Qazi, Begum, Rabeya, Reza, Md Salim
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bangladesh
Cohort Studies
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - pathology
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Analysis
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container_title Japanese journal of clinical oncology
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creator Shuayb, Md
Mehedi Hasan, Md
Hoque, Md Rashedul
Mushtaq Hussain, Qazi
Begum, Rabeya
Reza, Md Salim
description Prognostic factors in colorectal cancer have lesser been evaluated in developing countries. This study aims to determine overall survival and prognostic factors for metastatic colorectal cancer patients who were non-operable and received chemotherapy. The study retrospectively investigated 67 inoperable metastatic colorectal cancer patients at Square Hospital, Bangladesh. The primary endpoint was overall survival, and the secondary endpoints were prognostic association with factors. Survival probabilities were calculated by non-parametric Kaplan-Meier method and compared by log-rank test. Univariate and multivariable Cox proportional hazard models were implemented to assess the prognostic association. Median survival of the entire cohort was 14 months (95% confidence interval: 11-25). In multivariable analysis, two prognostic factors were independently associated with survival: Karnofsky performance status and carcinoembryonic antigen. Patients with Karnofsky performance status 100 ng/ml, respectively, while comparing with carcinoembryonic antigen
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This study aims to determine overall survival and prognostic factors for metastatic colorectal cancer patients who were non-operable and received chemotherapy. The study retrospectively investigated 67 inoperable metastatic colorectal cancer patients at Square Hospital, Bangladesh. The primary endpoint was overall survival, and the secondary endpoints were prognostic association with factors. Survival probabilities were calculated by non-parametric Kaplan-Meier method and compared by log-rank test. Univariate and multivariable Cox proportional hazard models were implemented to assess the prognostic association. Median survival of the entire cohort was 14 months (95% confidence interval: 11-25). In multivariable analysis, two prognostic factors were independently associated with survival: Karnofsky performance status and carcinoembryonic antigen. Patients with Karnofsky performance status &lt;70 had significant higher risk of death than those with Karnofsky performance status ≥70 (adjusted hazard ratio 4.25, 95% confidence interval: 2.15-8.39). Higher risk of death was found to be associated with higher carcinoembryonic antigen: adjusted hazard ratio was 1.72 (95% confidence interval: 0.81-3.68) and 2.96 (95% confidence interval: 1.25-7.01) for patients with carcinoembryonic antigen 10-100 and &gt;100 ng/ml, respectively, while comparing with carcinoembryonic antigen &lt;10 ng/ml. The presence of peritoneal metastasis and grade-III tumour significantly worsened the survival in univariate analysis (hazard ratio 2.46, 95% confidence interval: 1.32-4.57 and hazard ratio 1.74, 95% confidence interval: 1.01-3.03, respectively) but not in multivariable analysis (adjusted hazard ratio 1.92, 95% confidence interval: 0.88-4.18 and adjusted hazard ratio 1.25, 95% confidence interval: 0.66-2.36, respectively). The study reported survival of stage IV colorectal cancer patients undergo chemotherapy and identified that Karnofsky performance status and carcinoembryonic antigen are the poor prognostic factors to this cohort adjusting for other factors.</description><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyaa228</identifier><identifier>PMID: 33341898</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bangladesh ; Cohort Studies ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Survival Analysis</subject><ispartof>Japanese journal of clinical oncology, 2021-04, Vol.51 (4), p.552-559</ispartof><rights>The Author(s) 2020. Published by Oxford University Press. All rights reserved. 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This study aims to determine overall survival and prognostic factors for metastatic colorectal cancer patients who were non-operable and received chemotherapy. The study retrospectively investigated 67 inoperable metastatic colorectal cancer patients at Square Hospital, Bangladesh. The primary endpoint was overall survival, and the secondary endpoints were prognostic association with factors. Survival probabilities were calculated by non-parametric Kaplan-Meier method and compared by log-rank test. Univariate and multivariable Cox proportional hazard models were implemented to assess the prognostic association. Median survival of the entire cohort was 14 months (95% confidence interval: 11-25). In multivariable analysis, two prognostic factors were independently associated with survival: Karnofsky performance status and carcinoembryonic antigen. Patients with Karnofsky performance status &lt;70 had significant higher risk of death than those with Karnofsky performance status ≥70 (adjusted hazard ratio 4.25, 95% confidence interval: 2.15-8.39). Higher risk of death was found to be associated with higher carcinoembryonic antigen: adjusted hazard ratio was 1.72 (95% confidence interval: 0.81-3.68) and 2.96 (95% confidence interval: 1.25-7.01) for patients with carcinoembryonic antigen 10-100 and &gt;100 ng/ml, respectively, while comparing with carcinoembryonic antigen &lt;10 ng/ml. The presence of peritoneal metastasis and grade-III tumour significantly worsened the survival in univariate analysis (hazard ratio 2.46, 95% confidence interval: 1.32-4.57 and hazard ratio 1.74, 95% confidence interval: 1.01-3.03, respectively) but not in multivariable analysis (adjusted hazard ratio 1.92, 95% confidence interval: 0.88-4.18 and adjusted hazard ratio 1.25, 95% confidence interval: 0.66-2.36, respectively). 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source Oxford Journals Online
subjects Adult
Aged
Aged, 80 and over
Bangladesh
Cohort Studies
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - pathology
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Analysis
title Survival and prognostic association in stage IV colorectal cancer patients treated with chemotherapy in Bangladesh
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