Puerarin inhibits the development of osteoarthritis through antiinflammatory and antimatrix‐degrading pathways in osteoarthritis‐induced rat model

Puerarin is an isoflavone isolated from the medicinal plant Pueraria lobata. The purpose of this study was to study the antiinflammatory and antimatrix‐degrading effects of puerarin in a rat osteoarthritis (OA) model and its protective effects on joints. The rat OA model was established by anterior...

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Bibliographic Details
Published in:Phytotherapy research 2021-05, Vol.35 (5), p.2579-2593
Main Authors: Ma, Tian‐wen, Wen, Ya‐jing, Song, Xiao‐peng, Hu, Hai‐long, Li, Yue, Bai, Hui, Zhao, Ming‐chao, Gao, Li
Format: Article
Language:English
Subjects:
Animal tissues
Anterior cruciate ligament
Arthritis
articular cartilage
Biomarkers
Biomedical materials
Bone turnover
Cartilage
Cartilage diseases
Celecoxib
Collagen (type II)
Damage
Degradation
extracellular matrix
Herbal medicine
Inflammation
Joint diseases
Medicinal plants
Osteoarthritis
puerarin
Surgery
Tumor necrosis factor
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Summary:Puerarin is an isoflavone isolated from the medicinal plant Pueraria lobata. The purpose of this study was to study the antiinflammatory and antimatrix‐degrading effects of puerarin in a rat osteoarthritis (OA) model and its protective effects on joints. The rat OA model was established by anterior cruciate ligament transection (ACLT) surgery. Rats (n = 40) were divided into nontreated OA, OA + celecoxib (2.86 mg/kg), OA + puerarin (50 and 100 mg/kg), and control groups. Two weeks after surgical induction, puerarin was administered by gavage daily for 8 weeks. After 8 weeks, macroscopic observation and histopathological images showed that cartilage damage was reduced after puerarin and celecoxib treatment, the intensity of Safranin O staining was high, and the OARSI scores were significantly reduced compared to the OA group. Puerarin reduced the expression of MMP‐3, MMP‐13, ADAMTS‐5, and COX‐2 in the cartilage tissue of ACLT rats, inhibited the production of IL‐1β, IL‐6, and TNF‐α inflammatory factors, increased Type II collagen content, and altered the expression of serum OA cartilage degradation/bone turnover biomarkers (CTX‐I, CTX‐II, COMP, and PIINP). Based on these findings, we speculate that puerarin supplement to attain recovery from OA damage.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6988