Analysis of the chemical composition changes of Gardeniae Fructus before and after processing based on ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry

Gardeniae Fructus, the dry fruit of Gardenia jasminoides Ellis, has been widely used for the treatment of different diseases. Although four types of processed Gardeniae Fructus products, characterized by differing effects, are available for clinical use, little is known regarding the respective proc...

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Bibliographic Details
Published in:Journal of separation science 2021-03, Vol.44 (5), p.981-991
Main Authors: Li, Wenjing, Ren, Chenchen, Fei, Chenghao, Wang, Yulin, Xue, Qianqian, Li, Lin, Yin, Fangzhou, Li, Weidong
Format: Article
Language:English
Subjects:
Chemical composition
Chromatography
Gardeniae Fructus
iridoid glycosides
Liquid chromatography
Mass spectrometry
Multivariate statistical analysis
processing
Quadrupoles
Quality control
Scientific imaging
Spectroscopy
Statistical analysis
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Summary:Gardeniae Fructus, the dry fruit of Gardenia jasminoides Ellis, has been widely used for the treatment of different diseases. Although four types of processed Gardeniae Fructus products, characterized by differing effects, are available for clinical use, little is known regarding the respective processing mechanisms. In this study, ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry combined with multivariate statistical analysis was applied to characterize the chemical profiles of the differently processed Gardeniae Fructus products and to determine differences in their chemical compositions, thereby enabling us to identify those active compounds associated with the observed clinical effects. A total of 125 compounds were accordingly identified, among which, 56 were established as primary contributors to the significant differences (P 
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.202000957