Analysis of the chemical composition changes of Gardeniae Fructus before and after processing based on ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry

Gardeniae Fructus, the dry fruit of Gardenia jasminoides Ellis, has been widely used for the treatment of different diseases. Although four types of processed Gardeniae Fructus products, characterized by differing effects, are available for clinical use, little is known regarding the respective proc...

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Published in:Journal of separation science 2021-03, Vol.44 (5), p.981-991
Main Authors: Li, Wenjing, Ren, Chenchen, Fei, Chenghao, Wang, Yulin, Xue, Qianqian, Li, Lin, Yin, Fangzhou, Li, Weidong
Format: Article
Language:English
Subjects:
Chemical composition
Chromatography
Gardeniae Fructus
iridoid glycosides
Liquid chromatography
Mass spectrometry
Multivariate statistical analysis
processing
Quadrupoles
Quality control
Scientific imaging
Spectroscopy
Statistical analysis
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cited_by cdi_FETCH-LOGICAL-c4058-54c1bfad55b9469d0d4fce96f0d03e1b8d4f784a2b2bca691694b023ef6014c23
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container_issue 5
container_start_page 981
container_title Journal of separation science
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creator Li, Wenjing
Ren, Chenchen
Fei, Chenghao
Wang, Yulin
Xue, Qianqian
Li, Lin
Yin, Fangzhou
Li, Weidong
description Gardeniae Fructus, the dry fruit of Gardenia jasminoides Ellis, has been widely used for the treatment of different diseases. Although four types of processed Gardeniae Fructus products, characterized by differing effects, are available for clinical use, little is known regarding the respective processing mechanisms. In this study, ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry combined with multivariate statistical analysis was applied to characterize the chemical profiles of the differently processed Gardeniae Fructus products and to determine differences in their chemical compositions, thereby enabling us to identify those active compounds associated with the observed clinical effects. A total of 125 compounds were accordingly identified, among which, 56 were established as primary contributors to the significant differences (P 
doi_str_mv 10.1002/jssc.202000957
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Although four types of processed Gardeniae Fructus products, characterized by differing effects, are available for clinical use, little is known regarding the respective processing mechanisms. In this study, ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry combined with multivariate statistical analysis was applied to characterize the chemical profiles of the differently processed Gardeniae Fructus products and to determine differences in their chemical compositions, thereby enabling us to identify those active compounds associated with the observed clinical effects. A total of 125 compounds were accordingly identified, among which, 56 were established as primary contributors to the significant differences (P &lt; 0.01) between crude and processed Gardeniae Fructus, based on t‐test analysis. Furthermore, the potential mechanisms underlying the chemical transformations that occurred during processing were discussed. 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subjects Chemical composition
Chromatography
Gardeniae Fructus
iridoid glycosides
Liquid chromatography
Mass spectrometry
Multivariate statistical analysis
processing
Quadrupoles
Quality control
Scientific imaging
Spectroscopy
Statistical analysis
title Analysis of the chemical composition changes of Gardeniae Fructus before and after processing based on ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry
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