Clinicopathological features and current treatment outcomes of neuroendocrine thymic tumours

Abstract   OBJECTIVES Neuroendocrine thymic tumours (NETTs) are a distinct subgroup of rare malignancies. An international, multicentre retrospective analysis was used to study the clinicopathological features, current pattern of diagnosis, treatment and outcomes of patients with NETT. METHODS One h...

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Published in:European journal of cardio-thoracic surgery 2021-05, Vol.59 (5), p.1004-1013
Main Authors: Fang, Wentao, Filosso, Pier Luigi, Roden, Anja C, Gu, Zhitao, Liu, Yuan, Agzarian, John, Shen, Robert K, Ruffini, Enrico
Format: Article
Language:English
Subjects:
China
Europe
Humans
Neoplasm Staging
North America
Retrospective Studies
Thymoma - pathology
Thymus Neoplasms - pathology
Treatment Outcome
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Summary:Abstract   OBJECTIVES Neuroendocrine thymic tumours (NETTs) are a distinct subgroup of rare malignancies. An international, multicentre retrospective analysis was used to study the clinicopathological features, current pattern of diagnosis, treatment and outcomes of patients with NETT. METHODS One hundred and forty-six NETT treated from 1989 to 2016 at 21 centres in China, Europe and North America were retrospectively collected and reclassified according to the World Health Organization histological type and International Thymic Malignancy Interest Group (ITMIG)/International Association for Studies in Lung Cancer (IASLC)/Union for International Cancer Control (UICC) staging. Clinicopathological features, diagnostic and therapeutic approaches and outcomes were investigated. Results in the earlier and latter halves of the study period were also compared. RESULTS The pretreatment work-up relied exclusively on computed tomography in 85.6% (125/146) of cases. Most patients had advanced disease, with 32.2% (47/146) having lymph node involvement. Higher-grade histological type was associated with more advanced disease (P 
ISSN:1010-7940
1873-734X
DOI:10.1093/ejcts/ezaa453