The DNA methylation landscape of PD-1 ( PDCD1 ) and adjacent lncRNA AC131097.3 in head and neck squamous cell carcinoma

expression is associated with DNA methylation in head and neck squamous cell carcinomas (HNSCCs). We performed methylation analysis at single CpG site resolution in order to understand epigenetic regulation. CpG methylation analysis of and long non-coding RNA (lncRNA) was performed in n = 528 HNSCCs...

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Bibliographic Details
Published in:Epigenomics 2021-01, Vol.13 (2), p.113-127
Main Authors: Bockhorst, Christopher, Dietrich, Jörn, Vogt, Timo J, Stauber, Roland H, Strieth, Sebastian, Bootz, Friedrich, Dietrich, Dimo, Vos, Luka de
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Carcinoma, Squamous Cell - genetics
DNA Methylation - genetics
Epigenesis, Genetic - genetics
Gene Expression Regulation, Neoplastic - genetics
Head and Neck Neoplasms - genetics
Humans
Prognosis
Programmed Cell Death 1 Receptor - genetics
Promoter Regions, Genetic - genetics
RNA, Long Noncoding - genetics
Squamous Cell Carcinoma of Head and Neck - genetics
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Summary:expression is associated with DNA methylation in head and neck squamous cell carcinomas (HNSCCs). We performed methylation analysis at single CpG site resolution in order to understand epigenetic regulation. CpG methylation analysis of and long non-coding RNA (lncRNA) was performed in n = 528 HNSCCs and n = 50 normal adjacent tissues provided by The Cancer Genome Atlas and in isolated leukocytes. mRNA and lncRNA expression correlated inversely with promoter and positively with gene body CpG methylation. and are co-expressed. Methylation was sequence-contextually associated with human papillomavirus prognosis, mutational load, and immune infiltrates. The significance of and methylation is highly sequence-contextual. might play a role in HNSCC.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2020-0208