Impact of Arrhythmias on Hospitalizations in Patients With Cardiac Amyloidosis

Cardiac involvement in amyloidosis is associated with a poor prognosis. Data on the burden of arrhythmias in patients with cardiac amyloidosis (CA) during hospitalization are lacking. We identified the burden of arrhythmias using the National Inpatient Sample (NIS) database from January 2016 to Dece...

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Bibliographic Details
Published in:The American journal of cardiology 2021-03, Vol.143, p.125-130
Main Authors: Thakkar, Samarthkumar, Patel, Harsh P., Chowdhury, Medhat, Patel, Kirtenkumar, Kumar, Ashish, Arora, Shilpkumar, Zahid, Salman, Goel, Mishita, Barssoum, Kirolos, Jain, Vardhmaan, AbouEzzeddine, Omar F., DeSimone, Christopher V., Baibhav, Bipul, Rao, Mohan, Deshmukh, Abhishek
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amyloidosis
Amyloidosis - epidemiology
Arrhythmia
Arrhythmias, Cardiac - epidemiology
Atrial Fibrillation - epidemiology
Atrial Fibrillation - mortality
Atrial Flutter - epidemiology
Cardiac arrhythmia
Cardiomyopathies - epidemiology
Cardiomyopathy
Case-Control Studies
Codes
Comorbidity
Congestive heart failure
Disease
Disease Progression
Female
Fibrillation
Heart Arrest - epidemiology
Heart Block - epidemiology
Heart failure
Heart Failure - epidemiology
Hospital Costs - statistics & numerical data
Hospital Mortality
Hospitalization
Hospitalization - economics
Hospitalization - statistics & numerical data
Humans
Length of Stay - statistics & numerical data
Male
Middle Aged
Morbidity
Mortality
Prognosis
Propensity Score
Tachycardia, Supraventricular - epidemiology
Tachycardia, Ventricular - epidemiology
United States - epidemiology
Ventricular Fibrillation - epidemiology
Young Adult
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Description
Summary:Cardiac involvement in amyloidosis is associated with a poor prognosis. Data on the burden of arrhythmias in patients with cardiac amyloidosis (CA) during hospitalization are lacking. We identified the burden of arrhythmias using the National Inpatient Sample (NIS) database from January 2016 to December 2017. We compared patient characteristics, outcomes, and hospitalization costs between CA patients with and without documented arrhythmias. Out of 5,585 hospital admissions for CA, 2,020 (36.1%) had concurrent arrhythmias. Propensity-score matching for age, sex, income, and co-morbidities was performed with 1,405 CA patients with arrhythmias and 1,405 patients without. The primary outcome of all-cause mortality was significantly higher in CA patients with arrhythmia than without(13.9% vs 5.3%, p-value
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2020.12.024