The psychopathology of recurrent diabetic ketoacidosis: A case–control study

Background Despite its poor prognosis, the psychological factors associated with recurrent diabetic ketoacidosis are poorly understood. In people with type 1 diabetes, we assessed for psychopathology in those with and without recurrent diabetic ketoacidosis (DKA). Method The design was a case–contro...

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Bibliographic Details
Published in:Diabetic medicine 2021-07, Vol.38 (7), p.e14505-n/a
Main Authors: Garrett, Christopher J., Moulton, Calum D., Choudhary, Pratik, Amiel, Stephanie A., Fonagy, Peter, Ismail, Khalida
Format: Article
Language:English
Subjects:
Adult
Anxiety
Anxiety - diagnosis
Case-Control Studies
Depression - diagnosis
Diabetes
Diabetes mellitus (insulin dependent)
Diabetic ketoacidosis
Diabetic Ketoacidosis - psychology
Emotional Regulation
Female
Glycated Hemoglobin A - analysis
health care delivery
Humans
Ketoacidosis
Male
other complications
Personality
Personality Disorders - diagnosis
psychological aspects
Psychological Distress
Psychopathology
Recurrence
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Summary:Background Despite its poor prognosis, the psychological factors associated with recurrent diabetic ketoacidosis are poorly understood. In people with type 1 diabetes, we assessed for psychopathology in those with and without recurrent diabetic ketoacidosis (DKA). Method The design was a case–control study. Cases were defined as people with two or more DKA episodes in a 12‐month period (recurrent DKA). Cases and controls were matched for gender and age. We compared groups for scores on Beck's Anxiety Inventory (BAI), Beck's Depression Inventory II, Difficulty in Emotion Regulation Scale (DERS), Experiences in Close Relationships‐Revised, Standardised Assessment of Personality‐Abbreviated Scale (SAPAS), Interpersonal Problem Inventory, Eating Disorder Examination Questionnaire and Problem Areas in Diabetes (PAID) using unpaired t‐tests or Mann–Whitney U tests for parametric and non‐parametric data, respectively. Correction was made for multiple testing. Results In all, 23 cases and 23 controls were recruited with mean age 31.0 (11.4) years and 65.2% were men. Cases had higher HbA1c levels than controls (101.1 (23.2) vs. 85.7 (21.7) mmol/mol, (p = 0.02)). Compared to controls, people with recurrent DKA had higher scores on the BAI (p = 0.004), PAID (p = 0.004), DERS (p = 0.001) and SAPAS (p 
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.14505