A mortality risk score for septuagenarians undergoing orthotopic heart transplantation

Background With septuagenarians undergoing orthotopic heart transplantation (OHT) more frequently, we aimed to develop a risk score for 1‐year mortality in this population. Methods Septuagenarian OHT recipients were identified from the UNOS registry between 1987 and 2018. The primary outcome was 1‐y...

Full description

Saved in:
Bibliographic Details
Published in:Clinical transplantation 2021-03, Vol.35 (3), p.e14202-n/a
Main Authors: Diaz‐Castrillon, Carlos E., Seese, Laura, Hong, Yeahwa, Dufendach, Keith, Hickey, Gavin, Sultan, Ibrahim, Kilic, Arman
Format: Article
Language:English
Subjects:
Aged
cardiac transplant
Cohort Studies
Heart Transplantation
Humans
Logistic Models
recipient age
Retrospective Studies
Risk Factors
risk score
septuagenarian
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background With septuagenarians undergoing orthotopic heart transplantation (OHT) more frequently, we aimed to develop a risk score for 1‐year mortality in this population. Methods Septuagenarian OHT recipients were identified from the UNOS registry between 1987 and 2018. The primary outcome was 1‐year post‐OHT mortality. Patients were randomly divided into derivation and validation cohorts. Associated covariates were entered into a multivariable logistic regression model. A risk score was created using the magnitudes of the odds ratios from the derivation cohort, and its 1‐year post‐OHT mortality prediction capacity was tested in the validation cohort. Results A total of 1156 septuagenarians were included, and they were randomly divided into derivation (66.7%, n = 771) and validation (33.3%, n = 385) cohorts. An 11‐point risk score incorporating 4 variables was created, which included mechanical ventilation, serum bilirubin, serum creatinine, and donor age. The predicted 1‐year mortality ranged from 4.2% (0 points) to 48.1% (11‐points) (p 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14202