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Profiling and analysis of multiple constituents in Crataegi Fructus before and after processing by ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry

Rationale Crataegi Fructus (CF) is one of the most commonly used herbal medicines with a long history of clinical applications. CF is often processed to minimize gastric membrane irritation, although differently processed products can have different biological effects. The purpose of this study was...

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Bibliographic Details
Published in:Rapid communications in mass spectrometry 2021-04, Vol.35 (7), p.e9033-n/a
Main Authors: Xue, Qianqian, Wang, Yulin, Fei, Chenghao, Ren, Chenchen, Li, Wenjing, Li, Weidong, Yin, Fangzhou, Li, Lin
Format: Article
Language:English
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Summary:Rationale Crataegi Fructus (CF) is one of the most commonly used herbal medicines with a long history of clinical applications. CF is often processed to minimize gastric membrane irritation, although differently processed products can have different biological effects. The purpose of this study was to comprehensively identify the chemical composition of CF, determine the changes caused by processing, and elucidate the active constituents causing the clinical effects. This study aimed to define a theoretical basis for intensive mechanistic studies of CF processing and its reasonable clinical applications. Methods An optimized ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry (UHPLC/QqTOFMS) method in positive and negative ion modes, coupled with multivariate statistical analyses, was developed for the identification and analysis of chemical components in raw and processed products of CF. Results A total of 87 compounds were identified, including 61 marker compounds that were found to be primary contributors to the significant differences (p 
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.9033