Spherical agglomerates of lactose as potential carriers for inhalation

[Display omitted] We report here on spherical lactose agglomerates as potential carriers for inhalation applications. Micromeritic properties of three spherical lactose agglomerates (SA-A, SA-B, SA-C) and a standard lactose inhalation grade carrier (Lactohale 100; LH100) were evaluated and compared....

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Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 2021-02, Vol.159, p.11-20
Main Authors: Zellnitz, Sarah, Lamešić, Dejan, Stranzinger, Sandra, Pinto, Joana T., Planinšek, Odon, Paudel, Amrit
Format: Article
Language:English
Subjects:
Dry powder inhaler
Fine particle fraction
Inhalation
Lactose
Spherical agglomerates
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Summary:[Display omitted] We report here on spherical lactose agglomerates as potential carriers for inhalation applications. Micromeritic properties of three spherical lactose agglomerates (SA-A, SA-B, SA-C) and a standard lactose inhalation grade carrier (Lactohale 100; LH100) were evaluated and compared. Ordered mixtures with micronized salbutamol sulfate as the model active pharmaceutical ingredient (API) and lactose carriers at two drug loadings (2 wt%, 5 wt%) were prepared, and in-vitro aerosolization performance was assessed. The spherical crystallization process led to particles with tailored micromeritic properties. These had larger specific surface area and greater fine fraction 
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2020.12.015