Chemical constituents and their biological activities from the mushroom Pyropolyporus fomentarius

The chemical constituents and their biological activities of the mushroom Pyropolyporus fomentarius were investigated in this study. Two previously undescribed pentacyclic lupane-type triterpenes, 3-formyloxybetulin and 3-formyloxybetulinic acid, two rare degraded ergosterols, pyropolincisterols A a...

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Published in:Phytochemistry (Oxford) 2021-03, Vol.183, p.112625-112625, Article 112625
Main Authors: Zhang, Fa-Lei, Shi, Chen, Sun, Li-Tang, Yang, Hui-Xiang, He, Juan, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Format: Article
Language:English
Subjects:
Agaricales
Cytotoxicity
Ergosterols
Fruiting Bodies, Fungal
Macrophages
Molecular Structure
Nitric Oxide
NO production Inhibition
Polyporaceae
Pyropolyporus fomentarius
Steroids
Triterpenes - pharmacology
Triterpenoids
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Summary:The chemical constituents and their biological activities of the mushroom Pyropolyporus fomentarius were investigated in this study. Two previously undescribed pentacyclic lupane-type triterpenes, 3-formyloxybetulin and 3-formyloxybetulinic acid, two rare degraded ergosterols, pyropolincisterols A and B, along with ten known triterpenoids and four known ergosterols were isolated from the fruiting bodies of P. fomentarius. Their chemical structures were determined using a combination of spectroscopic analysis. Nine compounds exhibited certain cytotoxicities to human cancer cell lines, while polyporenic acid showed significant cytotoxicities to SMMC-7721 and A-549 with IC50 values less than 10 μM. Four compounds showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages with IC50 values of 36.3, 25.1, 21.4, and 34.2 μM, respectively. The results of this assessment suggested that the lanostane triterpenoids and ergosterols in fruiting bodies of P. fomentarius played key roles in its folk usages. Triterpenoids and ergosterols from mushroom Pyropolyporus fomentarius with cytotoxic and NO production inhibitory activities. [Display omitted] •A total of 18 compounds have been obtained from mushroom Pyropolyporus fomentarius.•Two compounds were rare carbon-degraded ergosterol derivatives.•Many compounds possess cytotoxicities and NO production inhibitory activities.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2020.112625