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Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry
Events of viral contaminations occurring during the production of biopharmaceuticals have been publicly reported by the biopharmaceutical industry. Upstream raw materials were often identified as the potential source of contamination. Viral contamination risk can be mitigated by inactivating or elim...
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| Published in: | Biotechnology progress 2021-05, Vol.37 (3), p.e3117-n/a |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3887-6e0c3fe75a59f797d5ef91576dac1fa5e8aa0923685f73c5688ab9a24977fc2f3 |
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| container_issue | 3 |
| container_start_page | e3117 |
| container_title | Biotechnology progress |
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| creator | Djemal, Leïla Fournier, Clemence Hagen, Joerg Kolmar, Harald Deparis, Véronique |
| description | Events of viral contaminations occurring during the production of biopharmaceuticals have been publicly reported by the biopharmaceutical industry. Upstream raw materials were often identified as the potential source of contamination. Viral contamination risk can be mitigated by inactivating or eliminating potential viruses of cell culture media and feed solutions. Different methods can be used alone or in combination on raw materials, cell culture media, or feed solutions such as viral inactivation technologies consisting mainly of high temperature short time, ultraviolet irradiation, and gamma radiation technologies or such as viral removal technology for instance nanofiltration. The aim of this review is to present the principle, the advantages, and the challenges of high temperature short time (HTST) technology. Here, we reviewed effectiveness of HTST treatment and its impact on media (filterability of media, degradation of components), on process performance (cell growth, cell metabolism, productivity), and product quality based on knowledge shared in the literature. |
| doi_str_mv | 10.1002/btpr.3117 |
| format | article |
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| ispartof | Biotechnology progress, 2021-05, Vol.37 (3), p.e3117-n/a |
| issn | 8756-7938 1520-6033 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Biopharmaceuticals Cell culture Cell Culture Techniques - methods Cell Culture Techniques - standards CHO Cells Contamination Cricetinae Cricetulus Culture media Culture Media - chemistry Culture Media - standards Deactivation Drug Contamination - prevention & control Drug Industry Filterability flash pasteurization Gamma rays HEK293 Cells High temperature high temperature short time Hot Temperature Humans Inactivation Irradiation Media Metabolism Nanofiltration Nanotechnology Pasteurization - methods precipitation Raw materials Technology Ultraviolet radiation virus Virus Inactivation - radiation effects Viruses Viruses - pathogenicity γ Radiation |
| title | Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry |
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