Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported,...

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Bibliographic Details
Published in:Organic letters 2021-01, Vol.23 (2), p.296-299
Main Authors: Yang, Shan, Liu, Lingling, Zhou, Zheng, Huang, Zhibin, Zhao, Yingsheng
Format: Article
Language:English
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Summary:We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c03773