Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported,...

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Published in:Organic letters 2021-01, Vol.23 (2), p.296-299
Main Authors: Yang, Shan, Liu, Lingling, Zhou, Zheng, Huang, Zhibin, Zhao, Yingsheng
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Language:English
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cited_by cdi_FETCH-LOGICAL-c305t-873d5d24ddd9561e91933bef5714fd0d7b7e72d557bae7f35ddfd8811620720d3
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container_title Organic letters
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creator Yang, Shan
Liu, Lingling
Zhou, Zheng
Huang, Zhibin
Zhao, Yingsheng
description We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.
doi_str_mv 10.1021/acs.orglett.0c03773
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title Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives
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