Effect of exercise training on functional capacity and body composition in myotonic dystrophy type 2 patients

Background Myotonic dystrophy type 2 (DM2) is a neuromuscular disorder characterized by myotonia and muscle weakness, with no medical treatment to prevent a decline in decline. It is unknown whether exercise training is effective in DM2. The aim of this study was to investigate the effect of exercis...

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Bibliographic Details
Published in:Muscle & nerve 2021-04, Vol.63 (4), p.477-483
Main Authors: Kontou, Eleni, Papadopoulos, Constantinos, Papadimas, Giorgos, Toubekis, Argyris, Bogdanis, Gregory, Xirou, Sophia, Kararizou, Evangelia, Methenitis, Spyridon, Terzis, Gerasimos
Format: Article
Language:English
Subjects:
6 min walk test
aerobic training
Aged
Aged, 80 and over
Blood pressure
Body composition
Body Composition - physiology
Body mass
Bone mass
Bone mineral density
Dystrophy
Exercise - physiology
Female
Fitness training programs
Hand Strength - physiology
Humans
Lean body mass
Male
Medical treatment
Middle Aged
Muscle Strength - physiology
Muscle Weakness - diagnosis
Muscle Weakness - physiopathology
Muscle, Skeletal - physiology
Muscles
Myotonia
Myotonic dystrophy
Myotonic Dystrophy - diagnosis
Myotonic Dystrophy - physiopathology
neuromuscular disorders
Patients
Physical Fitness - physiology
Physical training
resistance training
Strength training
Training
Walking - physiology
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Summary:Background Myotonic dystrophy type 2 (DM2) is a neuromuscular disorder characterized by myotonia and muscle weakness, with no medical treatment to prevent a decline in decline. It is unknown whether exercise training is effective in DM2. The aim of this study was to investigate the effect of exercise training on functional capacity and body composition in these patients. Methods Body composition and functional capacity were evaluated at the beginning (T1) and end (T2) of a 12 wk control period, and again after 16 wk of exercise training (T3) in 10 patients. Results No changes were recorded after the control period. Handgrip strength, 5× sit to stand, timed up and go, 6 min walk distance, lean body mass (LBM), and bone mineral density (BMD) increased while arterial pressure decreased after training. Conclusions These results suggest that supervised exercise training improves functional capacity, LBM, and BMD in ambulatory DM2 patients.
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.27156