Heart and kidney disease: a cardiovascular high-risk constellation

Chronic kidney disease (CKD) is associated with substantial cardiovascular morbidity and mortality. This is mediated by highly prevalent traditional cardiovascular risk factors such as arterial hypertension and diabetes mellitus in patients with CKD, but also by the presence of CKD-specific so-calle...

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Bibliographic Details
Published in:Herz 2021-06, Vol.46 (3), p.206-211
Main Authors: Schunk, Stefan J., Speer, Thimoteus, Fliser, Danilo
Format: Article
Language:English
Subjects:
Blood pressure
Calcification
Calcification (ectopic)
Cardiology
Cardiovascular diseases
Cigarette smoking
Constellations
Coronary artery disease
Diabetes
Diabetes mellitus
Drug addiction
Dyslipidemia
Health risks
Heart diseases
Hypertension
Inflammation
Internal Medicine
Kidney diseases
Kidneys
Main Topic
Medicine
Medicine & Public Health
Metabolic disorders
Morbidity
Optimal control
Oxidative stress
Risk analysis
Risk factors
Toxins
Weight reduction
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Summary:Chronic kidney disease (CKD) is associated with substantial cardiovascular morbidity and mortality. This is mediated by highly prevalent traditional cardiovascular risk factors such as arterial hypertension and diabetes mellitus in patients with CKD, but also by the presence of CKD-specific so-called nontraditional cardiovascular risk factors such as vascular calcification, uremic toxins, uremic dyslipidemia, inflammation, and oxidative stress. Therefore, the primary and secondary prevention of cardiovascular disease represents an important part of the care of patients with CKD. This entails optimal control of blood pressure and diabetes, treatment of the uremic dyslipidemia, as well as life-style modifying factors such as weight reduction and smoking cessation.
ISSN:0340-9937
1615-6692
DOI:10.1007/s00059-020-05012-z