Parecoxib Vs Paracetamol for Treatment of Acute Renal Colic Due to Ureteric Calculi: A Randomized Controlled Trial

To compare efficacy and safety of parecoxib and paracetamol for treatment of acute renal colic due to ureteric stones. A randomized, double blinded, controlled trial included adult patients presented to emergency department with acute renal colic due to ureteric calculi between June 2019 and August...

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Published in:Urology (Ridgewood, N.J.) N.J.), 2021-03, Vol.149, p.76-80
Main Authors: Al-Terki, Abdullatif, Hussain, Jaffar, El-Nahas, Ahmed R., Aloumi, Abdullatif, Al-Asfoor, Monira, Altamimi, Abbas AMT, Abdelhamid, Usama, Alkabbani, Majd, Al-Shaiji, Tariq F.
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - adverse effects
Adult
Emergency Service, Hospital - statistics & numerical data
Female
Humans
Infusions, Intravenous
Isoxazoles - administration & dosage
Isoxazoles - adverse effects
Male
Middle Aged
Pain Management - methods
Pain Management - statistics & numerical data
Pain Measurement - statistics & numerical data
Renal Colic - diagnosis
Renal Colic - drug therapy
Renal Colic - etiology
Treatment Outcome
Ureteral Calculi - complications
Ureteral Calculi - drug therapy
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Summary:To compare efficacy and safety of parecoxib and paracetamol for treatment of acute renal colic due to ureteric stones. A randomized, double blinded, controlled trial included adult patients presented to emergency department with acute renal colic due to ureteric calculi between June 2019 and August 2020. Patients with hypersensitivity to either drug, peptic ulcer, coronary ischemia, peripheral vascular or cerebrovascular disease, hepatic impairment (Child-Pugh score >10) or chronic kidney disease stage 4 or 5 were excluded. Eligible patients were randomized to group 1 who received 1g intravenous Paracetamol infusion or group 2 who received 40mg intravenous Parecoxib infusion. Pain analogue score was evaluated before treatment and 30 minutes afterwards. The primary endpoint was the need for rescue analgesia for persistent pain. Safety was evaluated by the incidence of adverse events. The study included 203 patients (102 in group 1 and 101 in group 2). Pretreatment patients’ data were comparable for both groups. The mean pain analogue score decrease from 7.6 to 3.8 in paracetamol group (P
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2020.12.017