Proteins moonlighting in tumor metabolism and epigenetics

Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells. T...

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Bibliographic Details
Published in:Frontiers of medicine 2021, Vol.15 (3), p.383-403
Main Authors: Lv, Lei, Lei, Qunying
Format: Article
Language:English
Subjects:
Cancer
Epigenetics
Gene expression
Medicine
Medicine & Public Health
Metabolism
moonlighting function
Review
tumor metabolism
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Summary:Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells. To respond to nutrient stress and to meet the requirements for rapid cell proliferation, cancer cells reprogram metabolic pathways to take up more glucose and coordinate the production of energy and intermediates for biosynthesis. Such actions involve gene expression and activity regulation by the moonlighting function of oncoproteins and metabolic enzymes. The signal −moonlighting protein −metabolism axis facilitates the adaptation of tumor cells under varying environment conditions and can be therapeutically targeted for cancer treatment.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-020-0818-1