Correlation of Intraoperative Optical Coherence Tomography of Crystalline Lens Diameter, Thickness, and Volume with Biometry and Age

• Published in: American journal of ophthalmology 2021-05, Vol.225, p.147-156
• Main Authors: Waring, George Oral, Chang, Daniel H., Rocha, Karolinne Maia, Gouvea, Larissa, Penatti, Raphael
• Format: Article
• Language: English
• Subjects: Age; Biometrics; Cataracts; Dimensional analysis; Eye surgery; Magnetic resonance imaging; Ultrasonic imaging
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2020.12.021

To characterize crystalline lens dimensions derived from in vivo spectral-domain optical coherence tomography (SD-OCT) and identify associations among these parameters, ocular biometry, and age. In this retrospective study, lens thickness (LT), lens diameter (LD), and lens volume (LV) were measured intraoperatively using SD-OCT in 293 eyes undergoing lens surgery. Correlations among LT, LD, LV, age, axial length (AL), and anterior chamber depth (ACD) were analyzed. Multiple regression analysis was performed to determine whether a combination of biometric data could predict LD and LV. Wide variations were observed in LT (3.6-5.7 mm), LD (7.5-11.9 mm), and LV (119.9-312.4 mm3) of aging eyes. Correlations among the 3 lens dimensions were statistically significant (LV-LT: r = 0.785; P < .001; LV-LD: r = 0.696; P < .001; and LT-LD: r = 0.121; P = .039). With age, the correlation coefficients of LT, LD, and LV were 0.526, 0.326, and 0.573, respectively (P < .001). Although there was significant correlation of AL with LT (r = −0.137; P = .002) and LD (r = 0.268; P < .001), it was not significant with LV (r = 0.084; P = .15). Subgroup analysis revealed that 19.8% of long eyes had LD >1 standard deviation (SD) above and that 5.2% had LD