Late recovery of the cardiopulmonary exercise capacity after transcatheter amplatzer device closures for atrial septal defects in adults

Transcatheter atrial septal defect (ASD) closures using an Amplatzer Septal Occluder (ASO) have been widely performed. Compared to children, we sometimes experience late recovery of exercise performance in adult patients. Our study aimed to evaluate the change in the cardiopulmonary exercise capacit...

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Bibliographic Details
Published in:Heart and vessels 2021-05, Vol.36 (5), p.710-716
Main Authors: Yoshiba, Shigeki, Kojima, Takuro, Oyanagi, Takayuki, Toda, Koichi, Osada, Yousuke, Muraji, Shota, Imamura, Tomohiko, Nakano, Shintaro, Makita, Shigeru, Kobayashi, Toshiki, Sumitomo, Naokata
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anaerobic threshold
Biomedical Engineering and Bioengineering
Carbon dioxide
Cardiac Catheterization - methods
Cardiac Surgery
Cardiology
Catheterization
Diameters
Echocardiography
Exercise Tolerance - physiology
Female
Follow-Up Studies
Heart
Heart Septal Defects, Atrial - physiopathology
Heart Septal Defects, Atrial - surgery
Hemodynamics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Oxygen consumption
Postoperative Period
Recovery
Recovery of Function
Retrospective Studies
Septal Occluder Device
Vanadium oxides
Vascular Surgery
Ventricle
Young Adult
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Summary:Transcatheter atrial septal defect (ASD) closures using an Amplatzer Septal Occluder (ASO) have been widely performed. Compared to children, we sometimes experience late recovery of exercise performance in adult patients. Our study aimed to evaluate the change in the cardiopulmonary exercise capacity in asymptomatic or mildly symptomatic adult patients after a transcatheter ASD closure using an ASO. The subjects consisted of 29 patients (age 39.5 ± 13.6 years) that underwent cardiopulmonary exercise testing (CPX) before, 3, 6, and 12 months after a transcatheter secundum ASD closure using an ASO. The peak oxygen consumption (peak VO 2 ), anaerobic threshold (AT), and slope of the correlation between the ventilation and carbon dioxide production (VE/VCO 2 slope) were evaluated. We also evaluated the left-ventricular end-diastolic diameter (LVEDD), right-ventricular end-diastolic dimension (RVEDD) by echocardiography, and hemodynamic values by cardiac catheterization before the ASO procedure. The peak VO 2 did not show any improvement 3 months after the ASO procedure; however, a significant improvement was displayed 6 and 12 months (baseline: 23.4 ± 6.3, 3 months: 23.6 ± 6.4, 6 months: 25.1 ± 5.6, 12 months: 26.4 ± 5.3 mL/kg/min; p  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-020-01741-7