An update on imaging of Paget’s sarcoma

Paget’s sarcoma is a rare and particularly aggressive tumour arising within pagetic bone, affecting approximately 1% of patients with Paget’s disease during the course of their disease. Most of these tumours are osteosarcomas, but the age profile, skeletal distribution and clinical outcomes differ c...

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Bibliographic Details
Published in:Skeletal radiology 2021-07, Vol.50 (7), p.1275-1290
Main Authors: Tilden, William, Saifuddin, Asif
Format: Article
Language:English
Subjects:
Age composition
Biomedical materials
Bone cancer
Computed tomography
Diagnostic imaging
Differential diagnosis
Imaging
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Orthopedics
Osteosarcoma
Pathology
Radiology
Review Article
Sarcoma
Tumors
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Description
Summary:Paget’s sarcoma is a rare and particularly aggressive tumour arising within pagetic bone, affecting approximately 1% of patients with Paget’s disease during the course of their disease. Most of these tumours are osteosarcomas, but the age profile, skeletal distribution and clinical outcomes differ considerably from conventional osteosarcoma. In this review, we outline the clinical, radiographic/CT, scintigraphic and magnetic resonance imaging features of Paget’s sarcoma. We also review the neoplastic and non-neoplastic mimics of Paget’s sarcoma that should be considered in the differential diagnosis when encountering an aggressive lesion within pagetic bone.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-020-03682-8