Electrochemical sensor based on glassy carbon electrode modified by polymelamine formaldehyde/graphene oxide nanocomposite for ultrasensitive detection of oxycodone

Polymelamine formaldehyde/graphene oxide (PMF/GO) nanocomposite was used, for the first time, to study the ultrasensitive and selective electrochemical detection of oxycodone (OXC). The successful characterization of PMF/GO was verified based on scanning electron microscopy (SEM), transmission elect...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2021-01, Vol.188 (1), p.1-1, Article 1
Main Authors: Khosropour, Hossein, Rezaei, Behzad, Alinajafi, Hossein A., Ensafi, Ali A.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Characterization and Evaluation of Materials
Chemical sensors
Chemistry
Chemistry and Materials Science
Diffraction
Electrochemical analysis
Electrochemical impedance spectroscopy
Electron microscopy
Formaldehyde
Fourier transforms
Glassy carbon
Graphene
Infrared spectroscopy
Microengineering
Microscopy
Nanochemistry
Nanocomposites
Nanotechnology
Original Paper
Raman spectroscopy
Sensors
Spectrum analysis
X-rays
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Summary:Polymelamine formaldehyde/graphene oxide (PMF/GO) nanocomposite was used, for the first time, to study the ultrasensitive and selective electrochemical detection of oxycodone (OXC). The successful characterization of PMF/GO was verified based on scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), and Raman spectroscopy. The modified GCE (PMF/GO-GCE) proved its electrocatalytic effect on OXC determination according to cyclic, linear sweep, and differential pulse voltammetry (CV, LSV, and DPV) and electrochemical impedance spectroscopy (EIS) studies. The developed sensor under optimal conditions offered a linear relationship in a limited range of  0.01 to 45 μmol L −1 with the limit of detection (LOD) of 2.0 nmol L −1 . The proposed PMF/GO-GCE sensor was effectively employed for the OXC detection in human urine and serum samples. Graphical abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-020-04655-3