Effects of tadalafil versus silodosin on voiding function in male patients with non‐neurogenic detrusor underactivity: A comparative study using propensity score matching

Objectives To investigate and compare the effects of tadalafil and silodosin on lower urinary tract symptoms and voiding functions in men with non‐neurogenic detrusor underactivity. Methods A total of 126 treatment‐naive men with lower urinary tract symptoms diagnosed as non‐neurogenic detrusor unde...

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Bibliographic Details
Published in:International journal of urology 2021-04, Vol.28 (4), p.411-416
Main Authors: Matsukawa, Yoshihisa, Majima, Tsuyoshi, Funahashi, Yasuhito, Fujita, Takashi, Ishida, Shohei, Kato, Masashi, Gotoh, Momokazu
Format: Article
Language:English
Subjects:
Bladder
bladder contractility
Contractility
detrusor underactivity
lower urinary tract symptoms
Prostate
silodosin
tadalafil
Urinary tract
Urogenital system
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Summary:Objectives To investigate and compare the effects of tadalafil and silodosin on lower urinary tract symptoms and voiding functions in men with non‐neurogenic detrusor underactivity. Methods A total of 126 treatment‐naive men with lower urinary tract symptoms diagnosed as non‐neurogenic detrusor underactivity received tadalafil (5 mg/day) or silodosin (8 mg/day) for 12 months. After propensity score matching, parameter changes from before administration to 12 months since treatment initiation were assessed based on subjective symptoms and urodynamic findings, including bladder contractility index and maximum urinary flow rate, and were compared between the tadalafil treatment group and the silodosin group. Detrusor underactivity was defined as bladder contractility index
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.14481