Clinical Outcomes After Urinary Diversion for Malignant Ureteral Obstruction Secondary to Non-urologic Cancer: An Analysis of 778 Cases

Background This study investigated patient outcomes after urinary diversion in order to manage malignant ureteral obstruction caused by non-urologic cancers and to evaluate predictive factors for overall survival. Methods The study retrospectively reviewed patients with non-urologic malignancies who...

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Bibliographic Details
Published in:Annals of surgical oncology 2021-04, Vol.28 (4), p.2367-2373
Main Authors: Heo, Ji Eun, Jeon, Dae Young, Lee, Jongsoo, Ham, Won Sik, Choi, Young Deuk, Jang, Won Sik
Format: Article
Language:English
Subjects:
Chemotherapy
Hemoglobin
Humans
Male
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Neoplasms - complications
Nephrostomy, Percutaneous
Oncology
Radiation therapy
Renal function
Retrospective Studies
Sodium
Stents
Surgery
Surgical Oncology
Survival
Ureter
Ureteral Obstruction - etiology
Ureteral Obstruction - surgery
Urinary Diversion
Urologic Oncology
Urological cancer
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Summary:Background This study investigated patient outcomes after urinary diversion in order to manage malignant ureteral obstruction caused by non-urologic cancers and to evaluate predictive factors for overall survival. Methods The study retrospectively reviewed patients with non-urologic malignancies who underwent ureteral stenting or percutaneous nephrostomy for ureteral obstruction between 2006 and 2014. The variables for predicting overall survival were identified by Cox regression analysis. Results The study enrolled 778 patients, including 522 patients who underwent ureteral stenting and 256 patients who underwent percutaneous nephrostomy. Renal function was assessed immediately and then 2 weeks after urinary diversion. The median survival period was 5 months (interquartile range [IQR] 2–12 months). A total of 708 patients died. The patients who received chemotherapy after urinary diversion had a survival gain of 7 months compared with the patients who did not receive subsequent chemotherapy ( p 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-09423-4