MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults

Arterial ischemic stroke (AIS) in young adults is less common in older adults, but the underlying pathogenesis and risk factors are more multi-faceted. The role of inherited thrombophilia such as 5, 10-methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphism, ( C677T and A1298C ), factor V of...

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Bibliographic Details
Published in:Metabolic brain disease 2021-03, Vol.36 (3), p.421-428
Main Authors: M’barek, Lamia, Sakka, Salma, Meghdiche, Fatma, Turki, Dhaker, Maalla, Khadija, Dammak, Mariem, Kallel, Choumous, Mhiri, Chokri
Format: Article
Language:English
Subjects:
5, 10-Methylenetetrahydrofolate reductase (FADH2)
Adults
Biochemistry
Biomedical and Life Sciences
Biomedicine
Chi-square test
Coagulation factors
Evaluation
Factor V
Gene polymorphism
Ischemia
Metabolic Diseases
Methylenetetrahydrofolate reductase
Mutation
Neurology
Neurosciences
Older people
Oncology
Original Article
Pathogenesis
Polymorphism
Prothrombin
Reductases
Regression models
Risk analysis
Risk factors
Statistical analysis
Statistical methods
Statistical tests
Stroke
Synergistic effect
Thrombophilia
Young adults
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Summary:Arterial ischemic stroke (AIS) in young adults is less common in older adults, but the underlying pathogenesis and risk factors are more multi-faceted. The role of inherited thrombophilia such as 5, 10-methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphism, ( C677T and A1298C ), factor V of Leiden ( FVL ) polymorphism, and the prothrombin G20210A mutations remains unclear. This study aims to evaluate the role of prothrombin genetic factor in AIS among young adults in Tunisia and to assess the synergistic effect between thrombogenic mutations in the pathogenesis of AIS. In this case-control study, blood samples were collected from patients and healthy controls, all matched for age and gender. The difference between them is evaluated by using the chi-square test. The odds ratio (OR) was carried out to evaluate the associations between each polymorphism and AIS risk using a binary logistic regression model. Values were considered statistically significant when p 
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-020-00663-7