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Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications
Purpose Third stage of labor complications are more prevalent following singleton vaginal deliveries of gestations conceived through in vitro fertilization (IVF) and fresh embryo transfer. This study aimed to evaluate these complications in pregnancies conceived through frozen-thawed embryo transfer...
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| Published in: | Archives of gynecology and obstetrics 2021-08, Vol.304 (2), p.531-537 |
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| cites | cdi_FETCH-LOGICAL-c375t-dec229a98c3c93fe95f00bf233a10f9336e4056352b18d2b5fd770f5a67b34ff3 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Wertheimer, Avital Hochberg, Alyssa Krispin, Eyal Sapir, Onit Ben-Haroush, Avi Altman, Eran Schohat, Tzippy Shufaro, Yoel |
| description | Purpose
Third stage of labor complications are more prevalent following singleton vaginal deliveries of gestations conceived through in vitro fertilization (IVF) and fresh embryo transfer. This study aimed to evaluate these complications in pregnancies conceived through frozen-thawed embryo transfer (FET), in which endometrial preparation differs from fresh cycles.
Methods
A cohort study of all singleton pregnancies conceived through IVF-FET who delivered vaginally at a tertiary medical center during 2007–2017. The study group consisted of 88 IVF-FET gestations (cases) that were matched to 176 spontaneous pregnancies based on age, gravidity, parity and gestational week at delivery (controls). The association between mode of conception and third stage of labor complication rate was examined.
Results
Baseline characteristics were similar between groups, except for a lower prevalence of induction of labor in the control group (23.3% vs. 36.3%,
p
= 0.03). The rate of post-partum hemorrhage (PPH), manual lysis and revision of the uterine cavity were all higher in pregnancies conceived through IVF-FET versus spontaneously (13.6% vs. 5.7%,
p
= 0.018; 17% vs. 2.3%,
p
|
| doi_str_mv | 10.1007/s00404-020-05935-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2475401681</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2550948849</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-dec229a98c3c93fe95f00bf233a10f9336e4056352b18d2b5fd770f5a67b34ff3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq2qqGyhf6AHZKkXLinjryQ-IgQUCYkLnC3HGUNoYm9tryr66zHdpUgcehjPyPPMa2teQr4y-M4AupMMIEE2wKEBpYVq-AeyYlLwBjrGPpIV6Jca2m6ffM75EYDxvm8_kX0hhO4VtCsyXKT4B0NTHuxvHCkuQ3qKtCQbssdEp0xtoFMYcY31CIWmKf-k3roSE_U1ysOURpqLvUcaPZ3tUC9dXNbz5GyZYsiHZM_bOeOXXT4gdxfnt2c_muuby6uz0-vGiU6VZkTHuba6d8Jp4VErDzB4LoRl4LUQLUpQrVB8YP3IB-XHrgOvbNsNQnovDsjxVned4q8N5mKWKTucZxswbrLhslMSWNuzin57hz7GTQr1d4YrBVr2vdSV4lvKpZhzQm_WaVpsejIMzIsDZuuAqQ6Yvw4YXoeOdtKbYcHx38jryisgtkCurXCP6e3t_8g-AzokkRs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2550948849</pqid></control><display><type>article</type><title>Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications</title><source>Springer Link</source><creator>Wertheimer, Avital ; Hochberg, Alyssa ; Krispin, Eyal ; Sapir, Onit ; Ben-Haroush, Avi ; Altman, Eran ; Schohat, Tzippy ; Shufaro, Yoel</creator><creatorcontrib>Wertheimer, Avital ; Hochberg, Alyssa ; Krispin, Eyal ; Sapir, Onit ; Ben-Haroush, Avi ; Altman, Eran ; Schohat, Tzippy ; Shufaro, Yoel</creatorcontrib><description>Purpose
Third stage of labor complications are more prevalent following singleton vaginal deliveries of gestations conceived through in vitro fertilization (IVF) and fresh embryo transfer. This study aimed to evaluate these complications in pregnancies conceived through frozen-thawed embryo transfer (FET), in which endometrial preparation differs from fresh cycles.
Methods
A cohort study of all singleton pregnancies conceived through IVF-FET who delivered vaginally at a tertiary medical center during 2007–2017. The study group consisted of 88 IVF-FET gestations (cases) that were matched to 176 spontaneous pregnancies based on age, gravidity, parity and gestational week at delivery (controls). The association between mode of conception and third stage of labor complication rate was examined.
Results
Baseline characteristics were similar between groups, except for a lower prevalence of induction of labor in the control group (23.3% vs. 36.3%,
p
= 0.03). The rate of post-partum hemorrhage (PPH), manual lysis and revision of the uterine cavity were all higher in pregnancies conceived through IVF-FET versus spontaneously (13.6% vs. 5.7%,
p
= 0.018; 17% vs. 2.3%,
p
< 0.001; and 21.6% vs. 6.8%,
p
< 0.001, respectively). Multivariate analysis adjusting for age, previous cesarean section, induction of labor, neonatal weight and use of analgesia demonstrated that deliveries following IVF-FET were independently associated with an increased risk for third stage of labor complications (estimated OR = 3.45,
p
= 0.0002).
Conclusion
IVF-FET is an independent risk factor for PPH, need for manual lysis and revision of the uterine cavity. Precautionary measures should be undertaken in the third stage in deliveries following IVF-FET, even if no other risk factors are present.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-020-05935-2</identifier><identifier>PMID: 33398506</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Childbirth & labor ; Endocrinology ; Gynecologic Endocrinology and Reproductive Medicine ; Gynecology ; Human Genetics ; In vitro fertilization ; Induced labor ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pregnancy</subject><ispartof>Archives of gynecology and obstetrics, 2021-08, Vol.304 (2), p.531-537</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-dec229a98c3c93fe95f00bf233a10f9336e4056352b18d2b5fd770f5a67b34ff3</citedby><cites>FETCH-LOGICAL-c375t-dec229a98c3c93fe95f00bf233a10f9336e4056352b18d2b5fd770f5a67b34ff3</cites><orcidid>0000-0003-1448-3405</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33398506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wertheimer, Avital</creatorcontrib><creatorcontrib>Hochberg, Alyssa</creatorcontrib><creatorcontrib>Krispin, Eyal</creatorcontrib><creatorcontrib>Sapir, Onit</creatorcontrib><creatorcontrib>Ben-Haroush, Avi</creatorcontrib><creatorcontrib>Altman, Eran</creatorcontrib><creatorcontrib>Schohat, Tzippy</creatorcontrib><creatorcontrib>Shufaro, Yoel</creatorcontrib><title>Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Third stage of labor complications are more prevalent following singleton vaginal deliveries of gestations conceived through in vitro fertilization (IVF) and fresh embryo transfer. This study aimed to evaluate these complications in pregnancies conceived through frozen-thawed embryo transfer (FET), in which endometrial preparation differs from fresh cycles.
Methods
A cohort study of all singleton pregnancies conceived through IVF-FET who delivered vaginally at a tertiary medical center during 2007–2017. The study group consisted of 88 IVF-FET gestations (cases) that were matched to 176 spontaneous pregnancies based on age, gravidity, parity and gestational week at delivery (controls). The association between mode of conception and third stage of labor complication rate was examined.
Results
Baseline characteristics were similar between groups, except for a lower prevalence of induction of labor in the control group (23.3% vs. 36.3%,
p
= 0.03). The rate of post-partum hemorrhage (PPH), manual lysis and revision of the uterine cavity were all higher in pregnancies conceived through IVF-FET versus spontaneously (13.6% vs. 5.7%,
p
= 0.018; 17% vs. 2.3%,
p
< 0.001; and 21.6% vs. 6.8%,
p
< 0.001, respectively). Multivariate analysis adjusting for age, previous cesarean section, induction of labor, neonatal weight and use of analgesia demonstrated that deliveries following IVF-FET were independently associated with an increased risk for third stage of labor complications (estimated OR = 3.45,
p
= 0.0002).
Conclusion
IVF-FET is an independent risk factor for PPH, need for manual lysis and revision of the uterine cavity. Precautionary measures should be undertaken in the third stage in deliveries following IVF-FET, even if no other risk factors are present.</description><subject>Childbirth & labor</subject><subject>Endocrinology</subject><subject>Gynecologic Endocrinology and Reproductive Medicine</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>In vitro fertilization</subject><subject>Induced labor</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU1P3DAQhq2qqGyhf6AHZKkXLinjryQ-IgQUCYkLnC3HGUNoYm9tryr66zHdpUgcehjPyPPMa2teQr4y-M4AupMMIEE2wKEBpYVq-AeyYlLwBjrGPpIV6Jca2m6ffM75EYDxvm8_kX0hhO4VtCsyXKT4B0NTHuxvHCkuQ3qKtCQbssdEp0xtoFMYcY31CIWmKf-k3roSE_U1ysOURpqLvUcaPZ3tUC9dXNbz5GyZYsiHZM_bOeOXXT4gdxfnt2c_muuby6uz0-vGiU6VZkTHuba6d8Jp4VErDzB4LoRl4LUQLUpQrVB8YP3IB-XHrgOvbNsNQnovDsjxVned4q8N5mKWKTucZxswbrLhslMSWNuzin57hz7GTQr1d4YrBVr2vdSV4lvKpZhzQm_WaVpsejIMzIsDZuuAqQ6Yvw4YXoeOdtKbYcHx38jryisgtkCurXCP6e3t_8g-AzokkRs</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Wertheimer, Avital</creator><creator>Hochberg, Alyssa</creator><creator>Krispin, Eyal</creator><creator>Sapir, Onit</creator><creator>Ben-Haroush, Avi</creator><creator>Altman, Eran</creator><creator>Schohat, Tzippy</creator><creator>Shufaro, Yoel</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1448-3405</orcidid></search><sort><creationdate>20210801</creationdate><title>Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications</title><author>Wertheimer, Avital ; Hochberg, Alyssa ; Krispin, Eyal ; Sapir, Onit ; Ben-Haroush, Avi ; Altman, Eran ; Schohat, Tzippy ; Shufaro, Yoel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-dec229a98c3c93fe95f00bf233a10f9336e4056352b18d2b5fd770f5a67b34ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Childbirth & labor</topic><topic>Endocrinology</topic><topic>Gynecologic Endocrinology and Reproductive Medicine</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>In vitro fertilization</topic><topic>Induced labor</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wertheimer, Avital</creatorcontrib><creatorcontrib>Hochberg, Alyssa</creatorcontrib><creatorcontrib>Krispin, Eyal</creatorcontrib><creatorcontrib>Sapir, Onit</creatorcontrib><creatorcontrib>Ben-Haroush, Avi</creatorcontrib><creatorcontrib>Altman, Eran</creatorcontrib><creatorcontrib>Schohat, Tzippy</creatorcontrib><creatorcontrib>Shufaro, Yoel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wertheimer, Avital</au><au>Hochberg, Alyssa</au><au>Krispin, Eyal</au><au>Sapir, Onit</au><au>Ben-Haroush, Avi</au><au>Altman, Eran</au><au>Schohat, Tzippy</au><au>Shufaro, Yoel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>304</volume><issue>2</issue><spage>531</spage><epage>537</epage><pages>531-537</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
Third stage of labor complications are more prevalent following singleton vaginal deliveries of gestations conceived through in vitro fertilization (IVF) and fresh embryo transfer. This study aimed to evaluate these complications in pregnancies conceived through frozen-thawed embryo transfer (FET), in which endometrial preparation differs from fresh cycles.
Methods
A cohort study of all singleton pregnancies conceived through IVF-FET who delivered vaginally at a tertiary medical center during 2007–2017. The study group consisted of 88 IVF-FET gestations (cases) that were matched to 176 spontaneous pregnancies based on age, gravidity, parity and gestational week at delivery (controls). The association between mode of conception and third stage of labor complication rate was examined.
Results
Baseline characteristics were similar between groups, except for a lower prevalence of induction of labor in the control group (23.3% vs. 36.3%,
p
= 0.03). The rate of post-partum hemorrhage (PPH), manual lysis and revision of the uterine cavity were all higher in pregnancies conceived through IVF-FET versus spontaneously (13.6% vs. 5.7%,
p
= 0.018; 17% vs. 2.3%,
p
< 0.001; and 21.6% vs. 6.8%,
p
< 0.001, respectively). Multivariate analysis adjusting for age, previous cesarean section, induction of labor, neonatal weight and use of analgesia demonstrated that deliveries following IVF-FET were independently associated with an increased risk for third stage of labor complications (estimated OR = 3.45,
p
= 0.0002).
Conclusion
IVF-FET is an independent risk factor for PPH, need for manual lysis and revision of the uterine cavity. Precautionary measures should be undertaken in the third stage in deliveries following IVF-FET, even if no other risk factors are present.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33398506</pmid><doi>10.1007/s00404-020-05935-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1448-3405</orcidid></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2021-08, Vol.304 (2), p.531-537 |
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| language | eng |
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| subjects | Childbirth & labor Endocrinology Gynecologic Endocrinology and Reproductive Medicine Gynecology Human Genetics In vitro fertilization Induced labor Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pregnancy |
| title | Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications |
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