NMDA receptor-independent LTP in mammalian nervous system

•LTP in the CNS is dependent on activation of the ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR), which is highly calcium-permeable.•However, various forms of NMDAR-independent LTP have been identified in diverse areas of the nervous system.•NMDAR-independent LTPs require activation of g...

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Bibliographic Details
Published in:Progress in neurobiology 2021-05, Vol.200, p.101986-101986, Article 101986
Main Author: Alkadhi, Karim A.
Format: Article
Language:English
Subjects:
5-HT3 receptor-dependent ganglionic LTP
Amygdala
Animals
Calcium - metabolism
Calcium permeable-AMPA receptor
cAMP dependent LTP
Cerebellar purkinje cells
GLuA2 subunit
Glutamates
Hippocampus - metabolism
Humans
Long-Term Potentiation
mGLuR
Receptors, N-Methyl-D-Aspartate - metabolism
Superior cervical ganglion
Synapses - metabolism
α7 nAChR-dependent LTP
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Summary:•LTP in the CNS is dependent on activation of the ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR), which is highly calcium-permeable.•However, various forms of NMDAR-independent LTP have been identified in diverse areas of the nervous system.•NMDAR-independent LTPs require activation of glutamate mGluR or other ionotropic receptors including α7-nAChR, 5-HT3R or CP-AMPAR. Long-term potentiation (LTP) of synaptic transmission is a form of activity-dependent synaptic plasticity that exists at most synapses in the nervous system. In the central nervous system (CNS), LTP has been recorded at numerous synapses and is a prime candidate mechanism associating activity-dependent plasticity with learning and memory. LTP involves long-lasting increase in synaptic strength with various underlying mechanisms. In the CNS, the predominant type of LTP is believed to be dependent on activation of the ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR), which is highly calcium-permeable. However, various forms of NMDAR-independent LTP have been identified in diverse areas of the nervous system. The NMDAR-independent LTP may require activation of glutamate metabotropic receptors (mGluR) or ionotropic receptors other than NMDAR such as nicotinic acetylcholine receptor (α7-nAChR), serotonin 5-HT3 receptor or calcium-permeable AMPA receptor (CP-AMPAR). In this review, NMDAR-independent LTP of various areas of the central and peripheral nervous systems are discussed.
ISSN:0301-0082
1873-5118
DOI:10.1016/j.pneurobio.2020.101986