Oral focal mucinosis: A multi‐institutional study and literature review

Background Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods Clinical data were collected from th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cutaneous pathology 2021-01, Vol.48 (1), p.24-33
Main Authors: Silva Cunha, John Lennon, Leite, Amanda Almeida, Castro Abrantes, Thamiris, Vervloet, Lorena Passoni, Lima Morais, Thayná Melo, Oliveira Paiva Neto, Gerson, Kimura, Tatiana Nayara Libório, Ferreira, Sônia Maria Soares, Albuquerque‐Júnior, Ricardo Luiz Cavalcanti, Abrahão, Aline Corrêa, Romañach, Mario José, Benevenuto de Andrade, Bruno Augusto, Almeida, Oslei Paes, Soares, Ciro Dantas
Format: Article
Language:English
Subjects:
CD34 antigen
connective tissue diseases
diagnosis
Differential diagnosis
Etiology
Gingiva
Immunohistochemistry
Lesions
Literature reviews
Maxillofacial
Oral cavity
oral focal mucinosis
oral pathology
Pathology
Vimentin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods Clinical data were collected from the records of five oral and maxillofacial pathology services. All cases were evaluated by hematoxylin and eosin staining, histochemistry, and immunohistochemistry (vimentin, S‐100, α‐SMA, CD34, and mast cell). Results The series comprised 14 females (66.7%) and seven males (33.3%), with a mean age of 48.2 ± 20.7 years (range: 8‐77 years) and a 2:1 female‐to‐male ratio. Most of the lesions affected the gingiva (n = 6, 28.6%) and presented clinically as asymptomatic sessile or pedunculated nodules with fibrous or hyperplasic appearance. All cases were negative for S‐100 protein, CD34, and α‐SMA and positive for Alcian blue staining. Conservative surgical excision was the treatment in all cases, and there was only one recurrence. Conclusion OFM is a rare benign disorder that is often clinically misdiagnosed as reactive lesions or benign proliferative processes. Dermatologists and pathologists should consider OFM in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located in the gingiva.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13813