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Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results:...
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Published in: | Nanomedicine (London, England) England), 2021-01, Vol.16 (1), p.5-17 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations.
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and CAPES/UNESP- Print Project. The FRA Maia acknowledges the Portuguese Foundation for Science and Technology (FCT) for her contract under the Transitional Rule DL 57/2016 (CTTI-57/18-I3BS(5)) and JM Oliveira for the financial support provided under the program ‘Investigador FCT’ (IF/01285/2015). M Carvalho thanks the IET Institution of Engineering and Technology for the financial support provided under the IET Harvey Research Prize 2017. |
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ISSN: | 1743-5889 1748-6963 |
DOI: | 10.2217/nnm-2020-0312 |