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Structural analysis of glycosaminoglycans from Oviductus ranae
Oviductus ranae ( O.ran. ) has been widely used as a tonic and a traditional animal-based Chinese medicine. O.ran. extracts have been reported to have numerous biological activities, including activities that are often associated with mammalian glycosaminoglycans such as anti-inflammatory, antiosteo...
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| Published in: | Glycoconjugate journal 2021-02, Vol.38 (1), p.25-33 |
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| Main Authors: | , , , , , , , |
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| container_title | Glycoconjugate journal |
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| creator | Huang, Haiyue Mao, Jin Liang, Quntao Lin, Jianghui Jiang, Lilong Liu, Shutao Sharp, Joshua S. Wei, Zheng |
| description | Oviductus ranae
(
O.ran.
) has been widely used as a tonic and a traditional animal-based Chinese medicine.
O.ran.
extracts have been reported to have numerous biological activities, including activities that are often associated with mammalian glycosaminoglycans such as anti-inflammatory, antiosteoperotic, and anti-asthmatic. Glycosaminoglycans are complex linear polysaccharides ubiquitous in mammals that possess a wide range of biological activities. However, their presence and possible structural characteristics within
O.ran.
were previously unknown. In this study, glycosaminoglycans were isolated from
O.ran.
and their disaccharide compositions were analyzed by liquid chromatography-ion trap/time-of-flight mass spectrometry (LC-MS-ITTOF). Heparan sulfate (HS)/heparin (HP), chondroitin sulfate (CS)/dermatan sulfate (DS) and hyaluronic acid (HA) were detected in
O.ran.
with varied disaccharide compositions. HS species contain highly acetylated disaccharides, and have various structures in their constituent chains. CS/DS chains also possess a heterogeneous structure with different sulfation patterns and densities. This novel structural information could help clarify the possible involvement of these polysaccharides in the biological activities of
O.ran.
. |
| doi_str_mv | 10.1007/s10719-020-09962-8 |
| format | article |
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(
O.ran.
) has been widely used as a tonic and a traditional animal-based Chinese medicine.
O.ran.
extracts have been reported to have numerous biological activities, including activities that are often associated with mammalian glycosaminoglycans such as anti-inflammatory, antiosteoperotic, and anti-asthmatic. Glycosaminoglycans are complex linear polysaccharides ubiquitous in mammals that possess a wide range of biological activities. However, their presence and possible structural characteristics within
O.ran.
were previously unknown. In this study, glycosaminoglycans were isolated from
O.ran.
and their disaccharide compositions were analyzed by liquid chromatography-ion trap/time-of-flight mass spectrometry (LC-MS-ITTOF). Heparan sulfate (HS)/heparin (HP), chondroitin sulfate (CS)/dermatan sulfate (DS) and hyaluronic acid (HA) were detected in
O.ran.
with varied disaccharide compositions. HS species contain highly acetylated disaccharides, and have various structures in their constituent chains. CS/DS chains also possess a heterogeneous structure with different sulfation patterns and densities. This novel structural information could help clarify the possible involvement of these polysaccharides in the biological activities of
O.ran.
.</description><identifier>ISSN: 0282-0080</identifier><identifier>EISSN: 1573-4986</identifier><identifier>DOI: 10.1007/s10719-020-09962-8</identifier><identifier>PMID: 33411075</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Asthma ; Biochemistry ; Biomedical and Life Sciences ; Chondroitin sulfate ; Chondroitin Sulfates - analysis ; Chromatography, Liquid ; Dermatan Sulfate - analogs & derivatives ; Dermatan Sulfate - analysis ; Disaccharides ; Disaccharides - analysis ; Disaccharides - isolation & purification ; Glycosaminoglycans ; Glycosaminoglycans - analysis ; Glycosaminoglycans - chemistry ; Glycosaminoglycans - isolation & purification ; Heparan sulfate ; Heparin ; Heparin - analysis ; Heparitin Sulfate - analysis ; Hyaluronic acid ; Inflammation ; Ions ; Life Sciences ; Liquid chromatography ; Mammals ; Mass Spectrometry - methods ; Mass spectroscopy ; Materia Medica - chemistry ; Original Article ; Pathology ; Polysaccharides ; Sensitivity and Specificity</subject><ispartof>Glycoconjugate journal, 2021-02, Vol.38 (1), p.25-33</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1079df21b93c1eea801482f54d634fcc62d59543f653a9a489840c46471377053</citedby><cites>FETCH-LOGICAL-c375t-1079df21b93c1eea801482f54d634fcc62d59543f653a9a489840c46471377053</cites><orcidid>0000-0001-6469-6711</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33411075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Haiyue</creatorcontrib><creatorcontrib>Mao, Jin</creatorcontrib><creatorcontrib>Liang, Quntao</creatorcontrib><creatorcontrib>Lin, Jianghui</creatorcontrib><creatorcontrib>Jiang, Lilong</creatorcontrib><creatorcontrib>Liu, Shutao</creatorcontrib><creatorcontrib>Sharp, Joshua S.</creatorcontrib><creatorcontrib>Wei, Zheng</creatorcontrib><title>Structural analysis of glycosaminoglycans from Oviductus ranae</title><title>Glycoconjugate journal</title><addtitle>Glycoconj J</addtitle><addtitle>Glycoconj J</addtitle><description>Oviductus ranae
(
O.ran.
) has been widely used as a tonic and a traditional animal-based Chinese medicine.
O.ran.
extracts have been reported to have numerous biological activities, including activities that are often associated with mammalian glycosaminoglycans such as anti-inflammatory, antiosteoperotic, and anti-asthmatic. Glycosaminoglycans are complex linear polysaccharides ubiquitous in mammals that possess a wide range of biological activities. However, their presence and possible structural characteristics within
O.ran.
were previously unknown. In this study, glycosaminoglycans were isolated from
O.ran.
and their disaccharide compositions were analyzed by liquid chromatography-ion trap/time-of-flight mass spectrometry (LC-MS-ITTOF). Heparan sulfate (HS)/heparin (HP), chondroitin sulfate (CS)/dermatan sulfate (DS) and hyaluronic acid (HA) were detected in
O.ran.
with varied disaccharide compositions. HS species contain highly acetylated disaccharides, and have various structures in their constituent chains. CS/DS chains also possess a heterogeneous structure with different sulfation patterns and densities. This novel structural information could help clarify the possible involvement of these polysaccharides in the biological activities of
O.ran.
.</description><subject>Asthma</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Chondroitin sulfate</subject><subject>Chondroitin Sulfates - analysis</subject><subject>Chromatography, Liquid</subject><subject>Dermatan Sulfate - analogs & derivatives</subject><subject>Dermatan Sulfate - analysis</subject><subject>Disaccharides</subject><subject>Disaccharides - analysis</subject><subject>Disaccharides - isolation & purification</subject><subject>Glycosaminoglycans</subject><subject>Glycosaminoglycans - analysis</subject><subject>Glycosaminoglycans - chemistry</subject><subject>Glycosaminoglycans - isolation & purification</subject><subject>Heparan sulfate</subject><subject>Heparin</subject><subject>Heparin - analysis</subject><subject>Heparitin Sulfate - analysis</subject><subject>Hyaluronic acid</subject><subject>Inflammation</subject><subject>Ions</subject><subject>Life Sciences</subject><subject>Liquid chromatography</subject><subject>Mammals</subject><subject>Mass Spectrometry - methods</subject><subject>Mass spectroscopy</subject><subject>Materia Medica - chemistry</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Polysaccharides</subject><subject>Sensitivity and Specificity</subject><issn>0282-0080</issn><issn>1573-4986</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMotlZfwIUMuHEzenKdZCNI8QaFLtR1SDOZMmUuNZkR-vZmnKrgwtUJnO__D_kQOsdwjQGym4AhwyoFAikoJUgqD9AU84ymTElxiKZAJEkBJEzQSQgbiCFG5DGaUMpwDPMpun3pfG-73psqMY2pdqEMSVsk62pn22DqsmmHp2lCUvi2TpYfZT7wIfERd6foqDBVcGf7OUNvD_ev86d0sXx8nt8tUksz3qXxlsoLgleKWuyckYCZJAVnuaCssFaQnCvOaCE4NcowqSQDywTLMM0y4HSGrsberW_fexc6XZfBuqoyjWv7oAnLBCZCgojo5R900_Y-fm2gFItllJFIkZGyvg3Bu0JvfVkbv9MY9GBXj3Z1tKu_7GoZQxf76n5Vu_wn8q0zAnQEQlw1a-d_b_9T-wnNMoMq</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Huang, Haiyue</creator><creator>Mao, Jin</creator><creator>Liang, Quntao</creator><creator>Lin, Jianghui</creator><creator>Jiang, Lilong</creator><creator>Liu, Shutao</creator><creator>Sharp, Joshua S.</creator><creator>Wei, Zheng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6469-6711</orcidid></search><sort><creationdate>20210201</creationdate><title>Structural analysis of glycosaminoglycans from Oviductus ranae</title><author>Huang, Haiyue ; Mao, Jin ; Liang, Quntao ; Lin, Jianghui ; Jiang, Lilong ; Liu, Shutao ; Sharp, Joshua S. ; Wei, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1079df21b93c1eea801482f54d634fcc62d59543f653a9a489840c46471377053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Asthma</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Chondroitin sulfate</topic><topic>Chondroitin Sulfates - analysis</topic><topic>Chromatography, Liquid</topic><topic>Dermatan Sulfate - analogs & derivatives</topic><topic>Dermatan Sulfate - analysis</topic><topic>Disaccharides</topic><topic>Disaccharides - analysis</topic><topic>Disaccharides - isolation & purification</topic><topic>Glycosaminoglycans</topic><topic>Glycosaminoglycans - analysis</topic><topic>Glycosaminoglycans - chemistry</topic><topic>Glycosaminoglycans - isolation & purification</topic><topic>Heparan sulfate</topic><topic>Heparin</topic><topic>Heparin - analysis</topic><topic>Heparitin Sulfate - analysis</topic><topic>Hyaluronic acid</topic><topic>Inflammation</topic><topic>Ions</topic><topic>Life Sciences</topic><topic>Liquid chromatography</topic><topic>Mammals</topic><topic>Mass Spectrometry - methods</topic><topic>Mass spectroscopy</topic><topic>Materia Medica - chemistry</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Polysaccharides</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Haiyue</creatorcontrib><creatorcontrib>Mao, Jin</creatorcontrib><creatorcontrib>Liang, Quntao</creatorcontrib><creatorcontrib>Lin, Jianghui</creatorcontrib><creatorcontrib>Jiang, Lilong</creatorcontrib><creatorcontrib>Liu, Shutao</creatorcontrib><creatorcontrib>Sharp, Joshua S.</creatorcontrib><creatorcontrib>Wei, Zheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Glycoconjugate journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Haiyue</au><au>Mao, Jin</au><au>Liang, Quntao</au><au>Lin, Jianghui</au><au>Jiang, Lilong</au><au>Liu, Shutao</au><au>Sharp, Joshua S.</au><au>Wei, Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural analysis of glycosaminoglycans from Oviductus ranae</atitle><jtitle>Glycoconjugate journal</jtitle><stitle>Glycoconj J</stitle><addtitle>Glycoconj J</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>38</volume><issue>1</issue><spage>25</spage><epage>33</epage><pages>25-33</pages><issn>0282-0080</issn><eissn>1573-4986</eissn><abstract>Oviductus ranae
(
O.ran.
) has been widely used as a tonic and a traditional animal-based Chinese medicine.
O.ran.
extracts have been reported to have numerous biological activities, including activities that are often associated with mammalian glycosaminoglycans such as anti-inflammatory, antiosteoperotic, and anti-asthmatic. Glycosaminoglycans are complex linear polysaccharides ubiquitous in mammals that possess a wide range of biological activities. However, their presence and possible structural characteristics within
O.ran.
were previously unknown. In this study, glycosaminoglycans were isolated from
O.ran.
and their disaccharide compositions were analyzed by liquid chromatography-ion trap/time-of-flight mass spectrometry (LC-MS-ITTOF). Heparan sulfate (HS)/heparin (HP), chondroitin sulfate (CS)/dermatan sulfate (DS) and hyaluronic acid (HA) were detected in
O.ran.
with varied disaccharide compositions. HS species contain highly acetylated disaccharides, and have various structures in their constituent chains. CS/DS chains also possess a heterogeneous structure with different sulfation patterns and densities. This novel structural information could help clarify the possible involvement of these polysaccharides in the biological activities of
O.ran.
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33411075</pmid><doi>10.1007/s10719-020-09962-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6469-6711</orcidid></addata></record> |
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| identifier | ISSN: 0282-0080 |
| ispartof | Glycoconjugate journal, 2021-02, Vol.38 (1), p.25-33 |
| issn | 0282-0080 1573-4986 |
| language | eng |
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| source | Springer Nature |
| subjects | Asthma Biochemistry Biomedical and Life Sciences Chondroitin sulfate Chondroitin Sulfates - analysis Chromatography, Liquid Dermatan Sulfate - analogs & derivatives Dermatan Sulfate - analysis Disaccharides Disaccharides - analysis Disaccharides - isolation & purification Glycosaminoglycans Glycosaminoglycans - analysis Glycosaminoglycans - chemistry Glycosaminoglycans - isolation & purification Heparan sulfate Heparin Heparin - analysis Heparitin Sulfate - analysis Hyaluronic acid Inflammation Ions Life Sciences Liquid chromatography Mammals Mass Spectrometry - methods Mass spectroscopy Materia Medica - chemistry Original Article Pathology Polysaccharides Sensitivity and Specificity |
| title | Structural analysis of glycosaminoglycans from Oviductus ranae |
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