Insufficient Cumulus Expansion and Poor Oocyte Retrieval in Endometriosis-Related Infertile Women

Endometriosis (EMs) is a common cause for female infertility, leading to the need for in vitro fertilization (IVF). In clinics, we found the operative oocyte retrieval to be more or less difficult in women with EMs. We hypothesized that EMs may be involved in the insufficient cumulus expansion that...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2021-05, Vol.28 (5), p.1412-1420
Main Authors: Yin, Yaoxue, Mao, Yundong, Liu, Anthony, Shu, Li, Yuan, Chun, Cui, Yugui, Hou, Zhen, Liu, Jiayin
Format: Article
Language:English
Subjects:
Cumulus Cells - metabolism
Embryology
Endometriosis - metabolism
Female
Fertilization in Vitro
Gene Expression
Humans
Infertility, Female - metabolism
Infertility: Original Article
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Oocyte Retrieval
Reproductive Medicine
Retrospective Studies
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Summary:Endometriosis (EMs) is a common cause for female infertility, leading to the need for in vitro fertilization (IVF). In clinics, we found the operative oocyte retrieval to be more or less difficult in women with EMs. We hypothesized that EMs may be involved in the insufficient cumulus expansion that partially explained the lower oocyte retrieval in EMs-related infertile women undergoing assisted reproductive technology (ART). To explore whether the insufficient cumulus expansion exists in EMs-related infertile women and whether there is a possible relationship between the insufficient cumulus expansion and the clinical phenomenon of difficulty in oocyte retrieval. Those infertile women undergoing IVF recorded in our database between January 2013 and October 2017 were included. The expression levels of cumulus expansion–related genes ( HAS2/PTGS2/PTX3/TNFAIP6 ) in the cumulus cells (CCs) from 19 infertile women with EMs and 24 controls were analyzed by real-time PCR. After that, 635 women with EMs-associated infertility (the EMs group) and 4634 women with male factor–associated infertility (the control group) were included in the retrospective analysis. The clinical outcomes were compared between the two groups. The relative mRNA levels of cumulus expansion–related genes were significantly decreased in the CCs from those infertile women with EMs when compared to the control group (all p  
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-020-00410-4