Thermal stability of cannabinoids in dried cannabis: a kinetic study

This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from − 20 to + 40 ∘ C lasting up t...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2022, Vol.414 (1), p.377-384
Main Authors: Meija, Juris, McRae, Garnet, Miles, Christopher O., Melanson, Jeremy E.
Format: Article
Language:English
Subjects:
ABCs 20th Anniversary
Analysis
Analytical Chemistry
Biochemistry
Cannabinoids
Cannabinoids - analysis
Cannabis
Cannabis - chemistry
Characterization and Evaluation of Materials
Chemical reaction, Rate of
Chemistry
Chemistry and Materials Science
Chromatography, High Pressure Liquid - methods
Decomposition (Chemistry)
Degradation
Food Science
High temperature
High temperature effects
Identification and classification
Kinetics
Laboratory Medicine
Liquid chromatography
Marijuana
Mass spectrometry
Mass spectroscopy
Methods
Monitoring/Environmental Analysis
Properties
Research Paper
Room temperature
Shelf life
Tandem Mass Spectrometry - methods
Temperature effects
Thermal stability
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Summary:This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from − 20 to + 40 ∘ C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-020-03098-2