The Rise of Molecular Glues

2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen—as “molecular glues” that induce neo-protein–protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this sto...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2021-01, Vol.184 (1), p.3-9
Main Author: Schreiber, Stuart L.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen—as “molecular glues” that induce neo-protein–protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story. 2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen—as “molecular glues” that induce neo-protein–protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2020.12.020